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CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications

CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and its...

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Autores principales: Bang, Seongsik, Jee, Seungyun, Son, Hwangkyu, Cha, Hyebin, Park, Hosub, Myung, Jaekyung, Ko, Joo Yeon, Kim, Hyunsung, Paik, Seungsam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406543/
https://www.ncbi.nlm.nih.gov/pubmed/36010209
http://dx.doi.org/10.3390/diagnostics12081859
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author Bang, Seongsik
Jee, Seungyun
Son, Hwangkyu
Cha, Hyebin
Park, Hosub
Myung, Jaekyung
Ko, Joo Yeon
Kim, Hyunsung
Paik, Seungsam
author_facet Bang, Seongsik
Jee, Seungyun
Son, Hwangkyu
Cha, Hyebin
Park, Hosub
Myung, Jaekyung
Ko, Joo Yeon
Kim, Hyunsung
Paik, Seungsam
author_sort Bang, Seongsik
collection PubMed
description CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and its precursor lesions, and its clinicopathological significance were investigated. CD47 expression was evaluated by immunohistochemistry in 152 cases of BCC and 71 cases of SCC. For comparison of CD47 expression, actinic keratosis (AK), squamous cell carcinoma in situ (SCCIS), keratoacanthoma (KA), and normal skin (NS) tissue were used. CD47 expression in BCC was significantly lower than that of SCC (p < 0.001). CD47 expression levels in SCC and KA were significantly higher than those of NS and AK (p < 0.05). High CD47 expression was significantly associated with the presence of ulceration (p = 0.005) and a deeper level of invasion (p = 0.011) in BCC. In addition, high CD47 expression was significantly associated with the presence of ulceration (p = 0.019) and larger tumor size (p = 0.004) in SCC. CD47 expression was associated with tumorigenesis and tumor progression in non-melanoma skin cancers.
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spelling pubmed-94065432022-08-26 CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications Bang, Seongsik Jee, Seungyun Son, Hwangkyu Cha, Hyebin Park, Hosub Myung, Jaekyung Ko, Joo Yeon Kim, Hyunsung Paik, Seungsam Diagnostics (Basel) Article CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and its precursor lesions, and its clinicopathological significance were investigated. CD47 expression was evaluated by immunohistochemistry in 152 cases of BCC and 71 cases of SCC. For comparison of CD47 expression, actinic keratosis (AK), squamous cell carcinoma in situ (SCCIS), keratoacanthoma (KA), and normal skin (NS) tissue were used. CD47 expression in BCC was significantly lower than that of SCC (p < 0.001). CD47 expression levels in SCC and KA were significantly higher than those of NS and AK (p < 0.05). High CD47 expression was significantly associated with the presence of ulceration (p = 0.005) and a deeper level of invasion (p = 0.011) in BCC. In addition, high CD47 expression was significantly associated with the presence of ulceration (p = 0.019) and larger tumor size (p = 0.004) in SCC. CD47 expression was associated with tumorigenesis and tumor progression in non-melanoma skin cancers. MDPI 2022-07-31 /pmc/articles/PMC9406543/ /pubmed/36010209 http://dx.doi.org/10.3390/diagnostics12081859 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bang, Seongsik
Jee, Seungyun
Son, Hwangkyu
Cha, Hyebin
Park, Hosub
Myung, Jaekyung
Ko, Joo Yeon
Kim, Hyunsung
Paik, Seungsam
CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
title CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
title_full CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
title_fullStr CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
title_full_unstemmed CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
title_short CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
title_sort cd47 expression in non-melanoma skin cancers and its clinicopathological implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406543/
https://www.ncbi.nlm.nih.gov/pubmed/36010209
http://dx.doi.org/10.3390/diagnostics12081859
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