Cargando…

The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1...

Descripción completa

Detalles Bibliográficos
Autores principales: Borgmann-Staudt, Anja, Michael, Simon, Sommerhaeuser, Greta, Fernández-González, Marta-Julia, Friedrich, Lucía Alacán, Klco-Brosius, Stephanie, Kepak, Tomas, Kruseova, Jarmila, Michel, Gisela, Panasiuk, Anna, Schmidt, Sandrin, Lotz, Laura, Balcerek, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406562/
https://www.ncbi.nlm.nih.gov/pubmed/36005191
http://dx.doi.org/10.3390/curroncol29080453
_version_ 1784774151633895424
author Borgmann-Staudt, Anja
Michael, Simon
Sommerhaeuser, Greta
Fernández-González, Marta-Julia
Friedrich, Lucía Alacán
Klco-Brosius, Stephanie
Kepak, Tomas
Kruseova, Jarmila
Michel, Gisela
Panasiuk, Anna
Schmidt, Sandrin
Lotz, Laura
Balcerek, Magdalena
author_facet Borgmann-Staudt, Anja
Michael, Simon
Sommerhaeuser, Greta
Fernández-González, Marta-Julia
Friedrich, Lucía Alacán
Klco-Brosius, Stephanie
Kepak, Tomas
Kruseova, Jarmila
Michel, Gisela
Panasiuk, Anna
Schmidt, Sandrin
Lotz, Laura
Balcerek, Magdalena
author_sort Borgmann-Staudt, Anja
collection PubMed
description CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615–5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401–4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.
format Online
Article
Text
id pubmed-9406562
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94065622022-08-26 The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors Borgmann-Staudt, Anja Michael, Simon Sommerhaeuser, Greta Fernández-González, Marta-Julia Friedrich, Lucía Alacán Klco-Brosius, Stephanie Kepak, Tomas Kruseova, Jarmila Michel, Gisela Panasiuk, Anna Schmidt, Sandrin Lotz, Laura Balcerek, Magdalena Curr Oncol Article CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615–5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401–4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account. MDPI 2022-08-15 /pmc/articles/PMC9406562/ /pubmed/36005191 http://dx.doi.org/10.3390/curroncol29080453 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borgmann-Staudt, Anja
Michael, Simon
Sommerhaeuser, Greta
Fernández-González, Marta-Julia
Friedrich, Lucía Alacán
Klco-Brosius, Stephanie
Kepak, Tomas
Kruseova, Jarmila
Michel, Gisela
Panasiuk, Anna
Schmidt, Sandrin
Lotz, Laura
Balcerek, Magdalena
The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
title The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
title_full The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
title_fullStr The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
title_full_unstemmed The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
title_short The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
title_sort use of assisted reproductive technology by european childhood cancer survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406562/
https://www.ncbi.nlm.nih.gov/pubmed/36005191
http://dx.doi.org/10.3390/curroncol29080453
work_keys_str_mv AT borgmannstaudtanja theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT michaelsimon theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT sommerhaeusergreta theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT fernandezgonzalezmartajulia theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT friedrichluciaalacan theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT klcobrosiusstephanie theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT kepaktomas theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT kruseovajarmila theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT michelgisela theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT panasiukanna theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT schmidtsandrin theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT lotzlaura theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT balcerekmagdalena theuseofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT borgmannstaudtanja useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT michaelsimon useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT sommerhaeusergreta useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT fernandezgonzalezmartajulia useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT friedrichluciaalacan useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT klcobrosiusstephanie useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT kepaktomas useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT kruseovajarmila useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT michelgisela useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT panasiukanna useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT schmidtsandrin useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT lotzlaura useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors
AT balcerekmagdalena useofassistedreproductivetechnologybyeuropeanchildhoodcancersurvivors