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The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406562/ https://www.ncbi.nlm.nih.gov/pubmed/36005191 http://dx.doi.org/10.3390/curroncol29080453 |
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author | Borgmann-Staudt, Anja Michael, Simon Sommerhaeuser, Greta Fernández-González, Marta-Julia Friedrich, Lucía Alacán Klco-Brosius, Stephanie Kepak, Tomas Kruseova, Jarmila Michel, Gisela Panasiuk, Anna Schmidt, Sandrin Lotz, Laura Balcerek, Magdalena |
author_facet | Borgmann-Staudt, Anja Michael, Simon Sommerhaeuser, Greta Fernández-González, Marta-Julia Friedrich, Lucía Alacán Klco-Brosius, Stephanie Kepak, Tomas Kruseova, Jarmila Michel, Gisela Panasiuk, Anna Schmidt, Sandrin Lotz, Laura Balcerek, Magdalena |
author_sort | Borgmann-Staudt, Anja |
collection | PubMed |
description | CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615–5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401–4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account. |
format | Online Article Text |
id | pubmed-9406562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94065622022-08-26 The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors Borgmann-Staudt, Anja Michael, Simon Sommerhaeuser, Greta Fernández-González, Marta-Julia Friedrich, Lucía Alacán Klco-Brosius, Stephanie Kepak, Tomas Kruseova, Jarmila Michel, Gisela Panasiuk, Anna Schmidt, Sandrin Lotz, Laura Balcerek, Magdalena Curr Oncol Article CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615–5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401–4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account. MDPI 2022-08-15 /pmc/articles/PMC9406562/ /pubmed/36005191 http://dx.doi.org/10.3390/curroncol29080453 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Borgmann-Staudt, Anja Michael, Simon Sommerhaeuser, Greta Fernández-González, Marta-Julia Friedrich, Lucía Alacán Klco-Brosius, Stephanie Kepak, Tomas Kruseova, Jarmila Michel, Gisela Panasiuk, Anna Schmidt, Sandrin Lotz, Laura Balcerek, Magdalena The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors |
title | The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors |
title_full | The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors |
title_fullStr | The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors |
title_full_unstemmed | The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors |
title_short | The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors |
title_sort | use of assisted reproductive technology by european childhood cancer survivors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406562/ https://www.ncbi.nlm.nih.gov/pubmed/36005191 http://dx.doi.org/10.3390/curroncol29080453 |
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