5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action

SIMPLE SUMMARY: In the present work, we found that 5-ALA, a natural precursor of heme, can hinder cell glycolysis, which is the main path of energy production for most cancer cells. More specifically, we found that 5-ALA can block an enzyme involved in glycolysis, called lactate dehydrogenase (LDH)....

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Detalles Bibliográficos
Autores principales: Grigalavicius, Mantas, Ezzatpanah, Somayeh, Papakyriakou, Athanasios, Raabe, Tine Therese Henriksen, Yannakopoulou, Konstantina, Theodossiou, Theodossis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406570/
https://www.ncbi.nlm.nih.gov/pubmed/36010996
http://dx.doi.org/10.3390/cancers14164003

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