Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways

Degenerative disc disease (DDD) is an important cause of low back pain. Repetitive tensile stress from the daily motion of the spine predisposes it to injury of the annulus fibrosus (AF) which causes IVD degeneration. This study aims to determine the causal relationship between mechanical stretch an...

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Detalles Bibliográficos
Autores principales: Chen, Cheng-Nan, Chang, Hsin-I, Yen, Chia-Kung, Liu, Wen-Lung, Huang, Kuo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406707/
https://www.ncbi.nlm.nih.gov/pubmed/36010676
http://dx.doi.org/10.3390/cells11162600

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