Hsp90: From Cellular to Organismal Proteostasis

Assuring a healthy proteome is indispensable for survival and organismal health. Proteome disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The essential molecular chaperone Hsp90 is a regulator of the heat shock response via HSF1 and a stabilizer of a plethora of...

Descripción completa

Detalles Bibliográficos
Autores principales: Somogyvári, Milán, Khatatneh, Saba, Sőti, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406713/
https://www.ncbi.nlm.nih.gov/pubmed/36010556
http://dx.doi.org/10.3390/cells11162479
_version_ 1784774188281626624
author Somogyvári, Milán
Khatatneh, Saba
Sőti, Csaba
author_facet Somogyvári, Milán
Khatatneh, Saba
Sőti, Csaba
author_sort Somogyvári, Milán
collection PubMed
description Assuring a healthy proteome is indispensable for survival and organismal health. Proteome disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The essential molecular chaperone Hsp90 is a regulator of the heat shock response via HSF1 and a stabilizer of a plethora of signaling proteins. In this review, we summarize the role of Hsp90 in the cellular and organismal regulation of proteome maintenance.
format Online
Article
Text
id pubmed-9406713
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94067132022-08-26 Hsp90: From Cellular to Organismal Proteostasis Somogyvári, Milán Khatatneh, Saba Sőti, Csaba Cells Review Assuring a healthy proteome is indispensable for survival and organismal health. Proteome disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The essential molecular chaperone Hsp90 is a regulator of the heat shock response via HSF1 and a stabilizer of a plethora of signaling proteins. In this review, we summarize the role of Hsp90 in the cellular and organismal regulation of proteome maintenance. MDPI 2022-08-10 /pmc/articles/PMC9406713/ /pubmed/36010556 http://dx.doi.org/10.3390/cells11162479 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Somogyvári, Milán
Khatatneh, Saba
Sőti, Csaba
Hsp90: From Cellular to Organismal Proteostasis
title Hsp90: From Cellular to Organismal Proteostasis
title_full Hsp90: From Cellular to Organismal Proteostasis
title_fullStr Hsp90: From Cellular to Organismal Proteostasis
title_full_unstemmed Hsp90: From Cellular to Organismal Proteostasis
title_short Hsp90: From Cellular to Organismal Proteostasis
title_sort hsp90: from cellular to organismal proteostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406713/
https://www.ncbi.nlm.nih.gov/pubmed/36010556
http://dx.doi.org/10.3390/cells11162479
work_keys_str_mv AT somogyvarimilan hsp90fromcellulartoorganismalproteostasis
AT khatatnehsaba hsp90fromcellulartoorganismalproteostasis
AT soticsaba hsp90fromcellulartoorganismalproteostasis

Ejemplares similares