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Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking

Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is a critical regulator among the proteins involved in en...

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Autores principales: Gundu, Chayanika, Arruri, Vijay Kumar, Yadav, Poonam, Navik, Umashanker, Kumar, Ashutosh, Amalkar, Veda Sudhir, Vikram, Ajit, Gaddam, Ravinder Reddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406725/
https://www.ncbi.nlm.nih.gov/pubmed/36010634
http://dx.doi.org/10.3390/cells11162557
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author Gundu, Chayanika
Arruri, Vijay Kumar
Yadav, Poonam
Navik, Umashanker
Kumar, Ashutosh
Amalkar, Veda Sudhir
Vikram, Ajit
Gaddam, Ravinder Reddy
author_facet Gundu, Chayanika
Arruri, Vijay Kumar
Yadav, Poonam
Navik, Umashanker
Kumar, Ashutosh
Amalkar, Veda Sudhir
Vikram, Ajit
Gaddam, Ravinder Reddy
author_sort Gundu, Chayanika
collection PubMed
description Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis.
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spelling pubmed-94067252022-08-26 Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking Gundu, Chayanika Arruri, Vijay Kumar Yadav, Poonam Navik, Umashanker Kumar, Ashutosh Amalkar, Veda Sudhir Vikram, Ajit Gaddam, Ravinder Reddy Cells Review Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis. MDPI 2022-08-17 /pmc/articles/PMC9406725/ /pubmed/36010634 http://dx.doi.org/10.3390/cells11162557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gundu, Chayanika
Arruri, Vijay Kumar
Yadav, Poonam
Navik, Umashanker
Kumar, Ashutosh
Amalkar, Veda Sudhir
Vikram, Ajit
Gaddam, Ravinder Reddy
Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
title Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
title_full Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
title_fullStr Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
title_full_unstemmed Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
title_short Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
title_sort dynamin-independent mechanisms of endocytosis and receptor trafficking
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406725/
https://www.ncbi.nlm.nih.gov/pubmed/36010634
http://dx.doi.org/10.3390/cells11162557
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