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Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is a critical regulator among the proteins involved in en...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406725/ https://www.ncbi.nlm.nih.gov/pubmed/36010634 http://dx.doi.org/10.3390/cells11162557 |
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author | Gundu, Chayanika Arruri, Vijay Kumar Yadav, Poonam Navik, Umashanker Kumar, Ashutosh Amalkar, Veda Sudhir Vikram, Ajit Gaddam, Ravinder Reddy |
author_facet | Gundu, Chayanika Arruri, Vijay Kumar Yadav, Poonam Navik, Umashanker Kumar, Ashutosh Amalkar, Veda Sudhir Vikram, Ajit Gaddam, Ravinder Reddy |
author_sort | Gundu, Chayanika |
collection | PubMed |
description | Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis. |
format | Online Article Text |
id | pubmed-9406725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94067252022-08-26 Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking Gundu, Chayanika Arruri, Vijay Kumar Yadav, Poonam Navik, Umashanker Kumar, Ashutosh Amalkar, Veda Sudhir Vikram, Ajit Gaddam, Ravinder Reddy Cells Review Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a “molecular scissor” to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis. MDPI 2022-08-17 /pmc/articles/PMC9406725/ /pubmed/36010634 http://dx.doi.org/10.3390/cells11162557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gundu, Chayanika Arruri, Vijay Kumar Yadav, Poonam Navik, Umashanker Kumar, Ashutosh Amalkar, Veda Sudhir Vikram, Ajit Gaddam, Ravinder Reddy Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking |
title | Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking |
title_full | Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking |
title_fullStr | Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking |
title_full_unstemmed | Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking |
title_short | Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking |
title_sort | dynamin-independent mechanisms of endocytosis and receptor trafficking |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406725/ https://www.ncbi.nlm.nih.gov/pubmed/36010634 http://dx.doi.org/10.3390/cells11162557 |
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