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From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review

Congenital infections represent a challenging and varied clinical scenario in which the brain is frequently involved. Therefore, fetal and neonatal neuro-imaging plays a pivotal role in reaching an accurate diagnosis and in predicting the clinical outcome. Congenital brain infections are characteriz...

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Autores principales: Lucignani, Giulia, Guarnera, Alessia, Rossi-Espagnet, Maria Camilla, Moltoni, Giulia, Antonelli, Amanda, Figà Talamanca, Lorenzo, Carducci, Chiara, Calo Carducci, Francesca Ippolita, Napolitano, Antonio, Gandolfo, Carlo, Campi, Francesca, Auriti, Cinzia, Parazzini, Cecilia, Longo, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406729/
https://www.ncbi.nlm.nih.gov/pubmed/36010101
http://dx.doi.org/10.3390/children9081210
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author Lucignani, Giulia
Guarnera, Alessia
Rossi-Espagnet, Maria Camilla
Moltoni, Giulia
Antonelli, Amanda
Figà Talamanca, Lorenzo
Carducci, Chiara
Calo Carducci, Francesca Ippolita
Napolitano, Antonio
Gandolfo, Carlo
Campi, Francesca
Auriti, Cinzia
Parazzini, Cecilia
Longo, Daniela
author_facet Lucignani, Giulia
Guarnera, Alessia
Rossi-Espagnet, Maria Camilla
Moltoni, Giulia
Antonelli, Amanda
Figà Talamanca, Lorenzo
Carducci, Chiara
Calo Carducci, Francesca Ippolita
Napolitano, Antonio
Gandolfo, Carlo
Campi, Francesca
Auriti, Cinzia
Parazzini, Cecilia
Longo, Daniela
author_sort Lucignani, Giulia
collection PubMed
description Congenital infections represent a challenging and varied clinical scenario in which the brain is frequently involved. Therefore, fetal and neonatal neuro-imaging plays a pivotal role in reaching an accurate diagnosis and in predicting the clinical outcome. Congenital brain infections are characterized by various clinical manifestations, ranging from nearly asymptomatic diseases to syndromic disorders, often associated with severe neurological symptoms. Brain damage results from the complex interaction among the infectious agent, its specific cellular tropism, and the stage of development of the central nervous system at the time of the maternal infection. Therefore, neuroradiological findings vary widely and are the result of complex events. An early detection is essential to establishing a proper diagnosis and prognosis, and to guarantee an optimal and prompt therapeutic perinatal management. Recently, emerging infective agents (i.e., Zika virus and SARS-CoV2) have been related to possible pre- and perinatal brain damage, thus expanding the spectrum of congenital brain infections. The purpose of this pictorial review is to provide an overview of the current knowledge on fetal and neonatal brain neuroimaging patterns in congenital brain infections used in clinical practice.
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spelling pubmed-94067292022-08-26 From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review Lucignani, Giulia Guarnera, Alessia Rossi-Espagnet, Maria Camilla Moltoni, Giulia Antonelli, Amanda Figà Talamanca, Lorenzo Carducci, Chiara Calo Carducci, Francesca Ippolita Napolitano, Antonio Gandolfo, Carlo Campi, Francesca Auriti, Cinzia Parazzini, Cecilia Longo, Daniela Children (Basel) Review Congenital infections represent a challenging and varied clinical scenario in which the brain is frequently involved. Therefore, fetal and neonatal neuro-imaging plays a pivotal role in reaching an accurate diagnosis and in predicting the clinical outcome. Congenital brain infections are characterized by various clinical manifestations, ranging from nearly asymptomatic diseases to syndromic disorders, often associated with severe neurological symptoms. Brain damage results from the complex interaction among the infectious agent, its specific cellular tropism, and the stage of development of the central nervous system at the time of the maternal infection. Therefore, neuroradiological findings vary widely and are the result of complex events. An early detection is essential to establishing a proper diagnosis and prognosis, and to guarantee an optimal and prompt therapeutic perinatal management. Recently, emerging infective agents (i.e., Zika virus and SARS-CoV2) have been related to possible pre- and perinatal brain damage, thus expanding the spectrum of congenital brain infections. The purpose of this pictorial review is to provide an overview of the current knowledge on fetal and neonatal brain neuroimaging patterns in congenital brain infections used in clinical practice. MDPI 2022-08-11 /pmc/articles/PMC9406729/ /pubmed/36010101 http://dx.doi.org/10.3390/children9081210 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lucignani, Giulia
Guarnera, Alessia
Rossi-Espagnet, Maria Camilla
Moltoni, Giulia
Antonelli, Amanda
Figà Talamanca, Lorenzo
Carducci, Chiara
Calo Carducci, Francesca Ippolita
Napolitano, Antonio
Gandolfo, Carlo
Campi, Francesca
Auriti, Cinzia
Parazzini, Cecilia
Longo, Daniela
From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
title From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
title_full From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
title_fullStr From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
title_full_unstemmed From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
title_short From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review
title_sort from fetal to neonatal neuroimaging in torch infections: a pictorial review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406729/
https://www.ncbi.nlm.nih.gov/pubmed/36010101
http://dx.doi.org/10.3390/children9081210
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