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Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer

We aimed to identify prognostic predictive factors of patients with penile squamous cell carcinoma (PSCC). This retrospective study reviewed the clinical and pathological data of patients with PSCC at 10 institutions in Japan between January 2008 and December 2019. The primary endpoint was cancer-sp...

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Autores principales: Kawase, Makoto, Takagi, Kimiaki, Kawada, Kei, Ishida, Takashi, Tomioka, Masayuki, Enomoto, Torai, Fujimoto, Shota, Taniguchi, Tomoki, Ito, Hiroki, Kameyama, Koji, Yamada, Toru, Kawase, Kota, Kato, Daiki, Takai, Manabu, Iinuma, Koji, Nakane, Keita, Koie, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406784/
https://www.ncbi.nlm.nih.gov/pubmed/36005170
http://dx.doi.org/10.3390/curroncol29080432
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author Kawase, Makoto
Takagi, Kimiaki
Kawada, Kei
Ishida, Takashi
Tomioka, Masayuki
Enomoto, Torai
Fujimoto, Shota
Taniguchi, Tomoki
Ito, Hiroki
Kameyama, Koji
Yamada, Toru
Kawase, Kota
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Nakane, Keita
Koie, Takuya
author_facet Kawase, Makoto
Takagi, Kimiaki
Kawada, Kei
Ishida, Takashi
Tomioka, Masayuki
Enomoto, Torai
Fujimoto, Shota
Taniguchi, Tomoki
Ito, Hiroki
Kameyama, Koji
Yamada, Toru
Kawase, Kota
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Nakane, Keita
Koie, Takuya
author_sort Kawase, Makoto
collection PubMed
description We aimed to identify prognostic predictive factors of patients with penile squamous cell carcinoma (PSCC). This retrospective study reviewed the clinical and pathological data of patients with PSCC at 10 institutions in Japan between January 2008 and December 2019. The primary endpoint was cancer-specific survival (CSS). We also identified useful predictive factors for CSS in patients with PSCC. In total, 64 patients with PSCC were enrolled. At the end of the follow-up period, 15 patients (23.4%) died owing to PSCC and six (9.4%) died owing to other causes. The 2- and 3-year CSS rates were 78.9% and 76.6%, respectively. Using the Kaplan–Meier method, the Eastern Cooperative Oncology Group performance status 0, serum albumin levels ≥ 4.2 g/dL, hemoglobin levels ≥ 13.2 g/dL, C-reactive protein levels < 0.21 mg/dL, clinical T stage ≤ 2, clinically negative lymph node (LN) status, and tumor size < 30 mm were associated with a significantly better CSS. In the multivariate analysis, the clinically positive LN status was a significant predictive factor for CSS in patients with PSCC. Further prospective large-scale and long-term studies are required to validate our findings.
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spelling pubmed-94067842022-08-26 Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer Kawase, Makoto Takagi, Kimiaki Kawada, Kei Ishida, Takashi Tomioka, Masayuki Enomoto, Torai Fujimoto, Shota Taniguchi, Tomoki Ito, Hiroki Kameyama, Koji Yamada, Toru Kawase, Kota Kato, Daiki Takai, Manabu Iinuma, Koji Nakane, Keita Koie, Takuya Curr Oncol Article We aimed to identify prognostic predictive factors of patients with penile squamous cell carcinoma (PSCC). This retrospective study reviewed the clinical and pathological data of patients with PSCC at 10 institutions in Japan between January 2008 and December 2019. The primary endpoint was cancer-specific survival (CSS). We also identified useful predictive factors for CSS in patients with PSCC. In total, 64 patients with PSCC were enrolled. At the end of the follow-up period, 15 patients (23.4%) died owing to PSCC and six (9.4%) died owing to other causes. The 2- and 3-year CSS rates were 78.9% and 76.6%, respectively. Using the Kaplan–Meier method, the Eastern Cooperative Oncology Group performance status 0, serum albumin levels ≥ 4.2 g/dL, hemoglobin levels ≥ 13.2 g/dL, C-reactive protein levels < 0.21 mg/dL, clinical T stage ≤ 2, clinically negative lymph node (LN) status, and tumor size < 30 mm were associated with a significantly better CSS. In the multivariate analysis, the clinically positive LN status was a significant predictive factor for CSS in patients with PSCC. Further prospective large-scale and long-term studies are required to validate our findings. MDPI 2022-08-01 /pmc/articles/PMC9406784/ /pubmed/36005170 http://dx.doi.org/10.3390/curroncol29080432 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kawase, Makoto
Takagi, Kimiaki
Kawada, Kei
Ishida, Takashi
Tomioka, Masayuki
Enomoto, Torai
Fujimoto, Shota
Taniguchi, Tomoki
Ito, Hiroki
Kameyama, Koji
Yamada, Toru
Kawase, Kota
Kato, Daiki
Takai, Manabu
Iinuma, Koji
Nakane, Keita
Koie, Takuya
Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer
title Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer
title_full Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer
title_fullStr Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer
title_full_unstemmed Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer
title_short Clinical Lymph Node Involvement as a Predictor for Cancer-Specific Survival in Patients with Penile Squamous Cell Cancer
title_sort clinical lymph node involvement as a predictor for cancer-specific survival in patients with penile squamous cell cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406784/
https://www.ncbi.nlm.nih.gov/pubmed/36005170
http://dx.doi.org/10.3390/curroncol29080432
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