Cargando…
Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions
The evidence supporting the use of pharmacological treatments in pediatric chronic pain is limited. Quantitative sensory testing (QST) and conditioned pain modulation evaluation (CPM) provide information on pain phenotype, which may help clinicians to tailor the treatment. This retrospective study a...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406785/ https://www.ncbi.nlm.nih.gov/pubmed/36010048 http://dx.doi.org/10.3390/children9081157 |
_version_ | 1784774205942792192 |
---|---|
author | Bruneau, Alice Ferland, Catherine E. Pérez-Medina-Carballo, Rafael Somaini, Marta Mohamed, Nada Curatolo, Michele Ouellet, Jean A. Ingelmo, Pablo |
author_facet | Bruneau, Alice Ferland, Catherine E. Pérez-Medina-Carballo, Rafael Somaini, Marta Mohamed, Nada Curatolo, Michele Ouellet, Jean A. Ingelmo, Pablo |
author_sort | Bruneau, Alice |
collection | PubMed |
description | The evidence supporting the use of pharmacological treatments in pediatric chronic pain is limited. Quantitative sensory testing (QST) and conditioned pain modulation evaluation (CPM) provide information on pain phenotype, which may help clinicians to tailor the treatment. This retrospective study aimed to evaluate the association between the use of QST/CPM phenotyping on the selection of the treatment for children with chronic pain conditions. We retrospectively analyzed the medical records of 208 female patients (mean age 15 ± 2 years) enrolled in an outpatient interdisciplinary pediatric complex pain center. Pain phenotype information (QST/CPM) of 106 patients was available to the prescribing physician. The records of 102 age- and sex-matched patients without QST/CPM were used as controls. The primary endpoint was the proportion of medications and interventions prescribed. The secondary endpoint was the duration of treatment. The QST/CPM group received less opioids (7% vs. 28%, respectively, p < 0.001), less anticonvulsants (6% vs. 25%, p < 0.001), and less interventional treatments (29% vs. 44%, p = 0.03) than controls. Patients with an optimal CPM result tended to be prescribed fewer antidepressants (2% vs. 18%, p = 0.01), and patients with signs of allodynia and/or temporal summation tended to be prescribed fewer NSAIDs (57% vs. 78%, p = 0.04). There was no difference in the duration of the treatments between the groups. QST/CPM testing appears to provide more targeted therapeutic options resulting in the overall drop in polypharmacy and reduced use of interventional treatments while remaining at least as effective as the standard of care. |
format | Online Article Text |
id | pubmed-9406785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94067852022-08-26 Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions Bruneau, Alice Ferland, Catherine E. Pérez-Medina-Carballo, Rafael Somaini, Marta Mohamed, Nada Curatolo, Michele Ouellet, Jean A. Ingelmo, Pablo Children (Basel) Article The evidence supporting the use of pharmacological treatments in pediatric chronic pain is limited. Quantitative sensory testing (QST) and conditioned pain modulation evaluation (CPM) provide information on pain phenotype, which may help clinicians to tailor the treatment. This retrospective study aimed to evaluate the association between the use of QST/CPM phenotyping on the selection of the treatment for children with chronic pain conditions. We retrospectively analyzed the medical records of 208 female patients (mean age 15 ± 2 years) enrolled in an outpatient interdisciplinary pediatric complex pain center. Pain phenotype information (QST/CPM) of 106 patients was available to the prescribing physician. The records of 102 age- and sex-matched patients without QST/CPM were used as controls. The primary endpoint was the proportion of medications and interventions prescribed. The secondary endpoint was the duration of treatment. The QST/CPM group received less opioids (7% vs. 28%, respectively, p < 0.001), less anticonvulsants (6% vs. 25%, p < 0.001), and less interventional treatments (29% vs. 44%, p = 0.03) than controls. Patients with an optimal CPM result tended to be prescribed fewer antidepressants (2% vs. 18%, p = 0.01), and patients with signs of allodynia and/or temporal summation tended to be prescribed fewer NSAIDs (57% vs. 78%, p = 0.04). There was no difference in the duration of the treatments between the groups. QST/CPM testing appears to provide more targeted therapeutic options resulting in the overall drop in polypharmacy and reduced use of interventional treatments while remaining at least as effective as the standard of care. MDPI 2022-08-02 /pmc/articles/PMC9406785/ /pubmed/36010048 http://dx.doi.org/10.3390/children9081157 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bruneau, Alice Ferland, Catherine E. Pérez-Medina-Carballo, Rafael Somaini, Marta Mohamed, Nada Curatolo, Michele Ouellet, Jean A. Ingelmo, Pablo Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions |
title | Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions |
title_full | Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions |
title_fullStr | Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions |
title_full_unstemmed | Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions |
title_short | Association between the Use of Quantitative Sensory Testing and Conditioned Pain Modulation and the Prescription of Medication and Interventional Procedures in Children with Chronic Pain Conditions |
title_sort | association between the use of quantitative sensory testing and conditioned pain modulation and the prescription of medication and interventional procedures in children with chronic pain conditions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406785/ https://www.ncbi.nlm.nih.gov/pubmed/36010048 http://dx.doi.org/10.3390/children9081157 |
work_keys_str_mv | AT bruneaualice associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT ferlandcatherinee associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT perezmedinacarballorafael associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT somainimarta associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT mohamednada associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT curatolomichele associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT ouelletjeana associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions AT ingelmopablo associationbetweentheuseofquantitativesensorytestingandconditionedpainmodulationandtheprescriptionofmedicationandinterventionalproceduresinchildrenwithchronicpainconditions |