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Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila

The reward system involved in hedonic food intake presents neuronal and behavioral dysregulations during obesity. Moreover, gut microbiota dysbiosis during obesity promotes low-grade inflammation in peripheral organs and in the brain contributing to metabolic alterations. The mechanisms underlying r...

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Autores principales: Huwart, Sabrina J. P., de Wouters d’Oplinter, Alice, Rastelli, Marialetizia, Van Hul, Matthias, de Vos, Willem M., Luquet, Serge, Cani, Patrice D., Everard, Amandine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406832/
https://www.ncbi.nlm.nih.gov/pubmed/36010611
http://dx.doi.org/10.3390/cells11162534
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author Huwart, Sabrina J. P.
de Wouters d’Oplinter, Alice
Rastelli, Marialetizia
Van Hul, Matthias
de Vos, Willem M.
Luquet, Serge
Cani, Patrice D.
Everard, Amandine
author_facet Huwart, Sabrina J. P.
de Wouters d’Oplinter, Alice
Rastelli, Marialetizia
Van Hul, Matthias
de Vos, Willem M.
Luquet, Serge
Cani, Patrice D.
Everard, Amandine
author_sort Huwart, Sabrina J. P.
collection PubMed
description The reward system involved in hedonic food intake presents neuronal and behavioral dysregulations during obesity. Moreover, gut microbiota dysbiosis during obesity promotes low-grade inflammation in peripheral organs and in the brain contributing to metabolic alterations. The mechanisms underlying reward dysregulations during obesity remain unclear. We investigated if inflammation affects the striatum during obesity using a cohort of control-fed or diet-induced obese (DIO) male mice. We tested the potential effects of specific gut bacteria on the reward system during obesity by administrating Akkermansia muciniphila daily or a placebo to DIO male mice. We showed that dysregulations of the food reward are associated with inflammation and alterations in the blood–brain barrier in the striatum of obese mice. We identified Akkermansia muciniphila as a novel actor able to improve the dysregulated reward behaviors associated with obesity, potentially through a decreased activation of inflammatory pathways and lipid-sensing ability in the striatum. These results open a new field of research and suggest that gut microbes can be considered as an innovative therapeutic approach to attenuate reward alterations in obesity. This study provides substance for further investigations of Akkermansia muciniphila-mediated behavioral improvements in other inflammatory neuropsychiatric disorders.
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spelling pubmed-94068322022-08-26 Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila Huwart, Sabrina J. P. de Wouters d’Oplinter, Alice Rastelli, Marialetizia Van Hul, Matthias de Vos, Willem M. Luquet, Serge Cani, Patrice D. Everard, Amandine Cells Article The reward system involved in hedonic food intake presents neuronal and behavioral dysregulations during obesity. Moreover, gut microbiota dysbiosis during obesity promotes low-grade inflammation in peripheral organs and in the brain contributing to metabolic alterations. The mechanisms underlying reward dysregulations during obesity remain unclear. We investigated if inflammation affects the striatum during obesity using a cohort of control-fed or diet-induced obese (DIO) male mice. We tested the potential effects of specific gut bacteria on the reward system during obesity by administrating Akkermansia muciniphila daily or a placebo to DIO male mice. We showed that dysregulations of the food reward are associated with inflammation and alterations in the blood–brain barrier in the striatum of obese mice. We identified Akkermansia muciniphila as a novel actor able to improve the dysregulated reward behaviors associated with obesity, potentially through a decreased activation of inflammatory pathways and lipid-sensing ability in the striatum. These results open a new field of research and suggest that gut microbes can be considered as an innovative therapeutic approach to attenuate reward alterations in obesity. This study provides substance for further investigations of Akkermansia muciniphila-mediated behavioral improvements in other inflammatory neuropsychiatric disorders. MDPI 2022-08-16 /pmc/articles/PMC9406832/ /pubmed/36010611 http://dx.doi.org/10.3390/cells11162534 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huwart, Sabrina J. P.
de Wouters d’Oplinter, Alice
Rastelli, Marialetizia
Van Hul, Matthias
de Vos, Willem M.
Luquet, Serge
Cani, Patrice D.
Everard, Amandine
Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
title Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
title_full Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
title_fullStr Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
title_full_unstemmed Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
title_short Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
title_sort food reward alterations during obesity are associated with inflammation in the striatum in mice: beneficial effects of akkermansia muciniphila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406832/
https://www.ncbi.nlm.nih.gov/pubmed/36010611
http://dx.doi.org/10.3390/cells11162534
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