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Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy

Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the population in most countries. In the context of diabetes, the vascular endothelium can play a crucial pathophysiological role. If a healthy endothelium—which is a dynamic endocrine organ with autocrine and paracrine...

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Autores principales: Munteanu, Constantin, Rotariu, Mariana, Turnea, Marius-Alexandru, Anghelescu, Aurelian, Albadi, Irina, Dogaru, Gabriela, Silișteanu, Sînziana Calina, Ionescu, Elena Valentina, Firan, Florentina Carmen, Ionescu, Anca Mirela, Oprea, Carmen, Onose, Gelu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406839/
https://www.ncbi.nlm.nih.gov/pubmed/36005129
http://dx.doi.org/10.3390/cimb44080233
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author Munteanu, Constantin
Rotariu, Mariana
Turnea, Marius-Alexandru
Anghelescu, Aurelian
Albadi, Irina
Dogaru, Gabriela
Silișteanu, Sînziana Calina
Ionescu, Elena Valentina
Firan, Florentina Carmen
Ionescu, Anca Mirela
Oprea, Carmen
Onose, Gelu
author_facet Munteanu, Constantin
Rotariu, Mariana
Turnea, Marius-Alexandru
Anghelescu, Aurelian
Albadi, Irina
Dogaru, Gabriela
Silișteanu, Sînziana Calina
Ionescu, Elena Valentina
Firan, Florentina Carmen
Ionescu, Anca Mirela
Oprea, Carmen
Onose, Gelu
author_sort Munteanu, Constantin
collection PubMed
description Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the population in most countries. In the context of diabetes, the vascular endothelium can play a crucial pathophysiological role. If a healthy endothelium—which is a dynamic endocrine organ with autocrine and paracrine activity—regulates vascular tone and permeability and assures a proper balance between coagulation and fibrinolysis, and vasodilation and vasoconstriction, then, in contrast, a dysfunctional endothelium has received increasing attention as a potential contributor to the pathogenesis of vascular disease in diabetes. Hyperglycemia is indicated to be the major causative factor in the development of endothelial dysfunction. Furthermore, many shreds of evidence suggest that the progression of insulin resistance in type 2 diabetes is parallel to the advancement of endothelial dysfunction in atherosclerosis. To present the state-of-the-art data regarding endothelial dysfunction in diabetic micro- and macroangiopathy, we constructed this literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We interrogated five medical databases: Elsevier, PubMed, PMC, PEDro, and ISI Web of Science.
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spelling pubmed-94068392022-08-26 Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy Munteanu, Constantin Rotariu, Mariana Turnea, Marius-Alexandru Anghelescu, Aurelian Albadi, Irina Dogaru, Gabriela Silișteanu, Sînziana Calina Ionescu, Elena Valentina Firan, Florentina Carmen Ionescu, Anca Mirela Oprea, Carmen Onose, Gelu Curr Issues Mol Biol Review Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the population in most countries. In the context of diabetes, the vascular endothelium can play a crucial pathophysiological role. If a healthy endothelium—which is a dynamic endocrine organ with autocrine and paracrine activity—regulates vascular tone and permeability and assures a proper balance between coagulation and fibrinolysis, and vasodilation and vasoconstriction, then, in contrast, a dysfunctional endothelium has received increasing attention as a potential contributor to the pathogenesis of vascular disease in diabetes. Hyperglycemia is indicated to be the major causative factor in the development of endothelial dysfunction. Furthermore, many shreds of evidence suggest that the progression of insulin resistance in type 2 diabetes is parallel to the advancement of endothelial dysfunction in atherosclerosis. To present the state-of-the-art data regarding endothelial dysfunction in diabetic micro- and macroangiopathy, we constructed this literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We interrogated five medical databases: Elsevier, PubMed, PMC, PEDro, and ISI Web of Science. MDPI 2022-07-28 /pmc/articles/PMC9406839/ /pubmed/36005129 http://dx.doi.org/10.3390/cimb44080233 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Munteanu, Constantin
Rotariu, Mariana
Turnea, Marius-Alexandru
Anghelescu, Aurelian
Albadi, Irina
Dogaru, Gabriela
Silișteanu, Sînziana Calina
Ionescu, Elena Valentina
Firan, Florentina Carmen
Ionescu, Anca Mirela
Oprea, Carmen
Onose, Gelu
Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy
title Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy
title_full Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy
title_fullStr Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy
title_full_unstemmed Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy
title_short Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy
title_sort topical reappraisal of molecular pharmacological approaches to endothelial dysfunction in diabetes mellitus angiopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406839/
https://www.ncbi.nlm.nih.gov/pubmed/36005129
http://dx.doi.org/10.3390/cimb44080233
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