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Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)

This prospective registry-based study aims to describe electrochemotherapy (ECT) modalities in basal cell carcinoma (BCC) patients and evaluate its efficacy, safety, and predictive factors. The International Network for Sharing Practices of Electrochemotherapy (InspECT) multicentre database was quer...

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Autores principales: Bertino, Giulia, Muir, Tobian, Odili, Joy, Groselj, Ales, Marconato, Roberto, Curatolo, Pietro, Kis, Erika, Lonkvist, Camilla Kjaer, Clover, James, Quaglino, Pietro, Kunte, Christian, Spina, Romina, Seccia, Veronica, de Terlizzi, Francesca, Campana, Luca Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406883/
https://www.ncbi.nlm.nih.gov/pubmed/36005161
http://dx.doi.org/10.3390/curroncol29080423
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author Bertino, Giulia
Muir, Tobian
Odili, Joy
Groselj, Ales
Marconato, Roberto
Curatolo, Pietro
Kis, Erika
Lonkvist, Camilla Kjaer
Clover, James
Quaglino, Pietro
Kunte, Christian
Spina, Romina
Seccia, Veronica
de Terlizzi, Francesca
Campana, Luca Giovanni
author_facet Bertino, Giulia
Muir, Tobian
Odili, Joy
Groselj, Ales
Marconato, Roberto
Curatolo, Pietro
Kis, Erika
Lonkvist, Camilla Kjaer
Clover, James
Quaglino, Pietro
Kunte, Christian
Spina, Romina
Seccia, Veronica
de Terlizzi, Francesca
Campana, Luca Giovanni
author_sort Bertino, Giulia
collection PubMed
description This prospective registry-based study aims to describe electrochemotherapy (ECT) modalities in basal cell carcinoma (BCC) patients and evaluate its efficacy, safety, and predictive factors. The International Network for Sharing Practices of Electrochemotherapy (InspECT) multicentre database was queried for BCC cases treated with bleomycin-ECT between 2008 and 2019 (n = 330 patients from seven countries, with 623 BCCs [median number: 1/patient; range: 1–7; size: 13 mm, range: 5–350; 85% were primary, and 80% located in the head and neck]). The procedure was carried out under local anaesthesia in 68% of cases, with the adjunct of mild sedation in the remaining 32%. Of 300 evaluable patients, 242 (81%) achieved a complete response (CR) after a single ECT course. Treatment naïvety (odds ratio [OR] 0.35, 95% confidence interval [C.I.] 0.19–0.67, p = 0.001) and coverage of deep tumour margin with electric pulses (O.R. 5.55, 95% C.I. 1.37–21.69, p = 0.016) predicted CR, whereas previous radiation was inversely correlated (O.R. 0.25, p = 0.0051). Toxicity included skin ulceration (overall, 16%; G3, 1%) and hyperpigmentation (overall, 8.1%; G3, 2.5%). At a 17-month follow-up, 28 (9.3%) patients experienced local recurrence/progression. Despite no convincing evidence that ECT confers improved outcomes compared with standard surgical excision, it can still be considered an opportunity to avoid major resection in patients unsuitable for more demanding treatment. Treatment naïvety and coverage of the deep margin predict tumour clearance and may inform current patient selection and management.
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spelling pubmed-94068832022-08-26 Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019) Bertino, Giulia Muir, Tobian Odili, Joy Groselj, Ales Marconato, Roberto Curatolo, Pietro Kis, Erika Lonkvist, Camilla Kjaer Clover, James Quaglino, Pietro Kunte, Christian Spina, Romina Seccia, Veronica de Terlizzi, Francesca Campana, Luca Giovanni Curr Oncol Article This prospective registry-based study aims to describe electrochemotherapy (ECT) modalities in basal cell carcinoma (BCC) patients and evaluate its efficacy, safety, and predictive factors. The International Network for Sharing Practices of Electrochemotherapy (InspECT) multicentre database was queried for BCC cases treated with bleomycin-ECT between 2008 and 2019 (n = 330 patients from seven countries, with 623 BCCs [median number: 1/patient; range: 1–7; size: 13 mm, range: 5–350; 85% were primary, and 80% located in the head and neck]). The procedure was carried out under local anaesthesia in 68% of cases, with the adjunct of mild sedation in the remaining 32%. Of 300 evaluable patients, 242 (81%) achieved a complete response (CR) after a single ECT course. Treatment naïvety (odds ratio [OR] 0.35, 95% confidence interval [C.I.] 0.19–0.67, p = 0.001) and coverage of deep tumour margin with electric pulses (O.R. 5.55, 95% C.I. 1.37–21.69, p = 0.016) predicted CR, whereas previous radiation was inversely correlated (O.R. 0.25, p = 0.0051). Toxicity included skin ulceration (overall, 16%; G3, 1%) and hyperpigmentation (overall, 8.1%; G3, 2.5%). At a 17-month follow-up, 28 (9.3%) patients experienced local recurrence/progression. Despite no convincing evidence that ECT confers improved outcomes compared with standard surgical excision, it can still be considered an opportunity to avoid major resection in patients unsuitable for more demanding treatment. Treatment naïvety and coverage of the deep margin predict tumour clearance and may inform current patient selection and management. MDPI 2022-07-28 /pmc/articles/PMC9406883/ /pubmed/36005161 http://dx.doi.org/10.3390/curroncol29080423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bertino, Giulia
Muir, Tobian
Odili, Joy
Groselj, Ales
Marconato, Roberto
Curatolo, Pietro
Kis, Erika
Lonkvist, Camilla Kjaer
Clover, James
Quaglino, Pietro
Kunte, Christian
Spina, Romina
Seccia, Veronica
de Terlizzi, Francesca
Campana, Luca Giovanni
Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)
title Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)
title_full Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)
title_fullStr Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)
title_full_unstemmed Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)
title_short Treatment of Basal Cell Carcinoma with Electrochemotherapy: Insights from the InspECT Registry (2008–2019)
title_sort treatment of basal cell carcinoma with electrochemotherapy: insights from the inspect registry (2008–2019)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406883/
https://www.ncbi.nlm.nih.gov/pubmed/36005161
http://dx.doi.org/10.3390/curroncol29080423
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