Cargando…

Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms

Some ovarian mucinous tumors are thought to originate from Brenner tumors and teratomas; however, data are limited on what could be the origin for the remaining tumors. We report a new case of ovarian mucinous borderline tumor/atypical proliferative mucinous tumor (MBT/APMT) co-existing with a meson...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jie, Dong, Yuling, Zhou, Xiaoqiu, Finkelman, Brian S., Xing, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406890/
https://www.ncbi.nlm.nih.gov/pubmed/36010251
http://dx.doi.org/10.3390/diagnostics12081901
_version_ 1784774231827939328
author Zhang, Jie
Dong, Yuling
Zhou, Xiaoqiu
Finkelman, Brian S.
Xing, Deyin
author_facet Zhang, Jie
Dong, Yuling
Zhou, Xiaoqiu
Finkelman, Brian S.
Xing, Deyin
author_sort Zhang, Jie
collection PubMed
description Some ovarian mucinous tumors are thought to originate from Brenner tumors and teratomas; however, data are limited on what could be the origin for the remaining tumors. We report a new case of ovarian mucinous borderline tumor/atypical proliferative mucinous tumor (MBT/APMT) co-existing with a mesonephric-like proliferation (MLP)/mesonephric-like hyperplasia (MLH). The patient was a 58-year-old woman who presented with a pelvic mass and abdominal pain. Pathology demonstrated an 11 cm MBT/APMT in the left ovary. In addition, the tumor contained one focal area (<1% of total tumor volume) of MLP/hyperplasia adjacent to, or intimately admixed with, mucinous epithelium, with an immunophenotype of diffuse Pax8 and Gata3 expression and negative TTF-1, ER, and PR staining. Pax8 was also weakly positive in the MBT/APMT component. Some mesonephric-like glands partially exhibited gastrointestinal-type mucinous metaplasia/differentiation. A polymerase chain reaction (PCR)-based Sanger sequencing demonstrated that a KRAS G12V mutation was present in both MLP/MLH and MBT/APMT components, providing further evidence to support their clonal relationship. We previously reported a series of similar cases and demonstrated a novel association between MLP, mesonephric-like adenocarcinoma and ovarian mucinous tumor. It is conceivable that benign MLPs may have ability to differentiate to lineage-specific mucinous lesions, and, as such, they may serve as a possible new origin of some ovarian mucinous neoplasms; in particular, Pax8-positive tumors. The current case provides additional evidence to support this theory.
format Online
Article
Text
id pubmed-9406890
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94068902022-08-26 Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms Zhang, Jie Dong, Yuling Zhou, Xiaoqiu Finkelman, Brian S. Xing, Deyin Diagnostics (Basel) Case Report Some ovarian mucinous tumors are thought to originate from Brenner tumors and teratomas; however, data are limited on what could be the origin for the remaining tumors. We report a new case of ovarian mucinous borderline tumor/atypical proliferative mucinous tumor (MBT/APMT) co-existing with a mesonephric-like proliferation (MLP)/mesonephric-like hyperplasia (MLH). The patient was a 58-year-old woman who presented with a pelvic mass and abdominal pain. Pathology demonstrated an 11 cm MBT/APMT in the left ovary. In addition, the tumor contained one focal area (<1% of total tumor volume) of MLP/hyperplasia adjacent to, or intimately admixed with, mucinous epithelium, with an immunophenotype of diffuse Pax8 and Gata3 expression and negative TTF-1, ER, and PR staining. Pax8 was also weakly positive in the MBT/APMT component. Some mesonephric-like glands partially exhibited gastrointestinal-type mucinous metaplasia/differentiation. A polymerase chain reaction (PCR)-based Sanger sequencing demonstrated that a KRAS G12V mutation was present in both MLP/MLH and MBT/APMT components, providing further evidence to support their clonal relationship. We previously reported a series of similar cases and demonstrated a novel association between MLP, mesonephric-like adenocarcinoma and ovarian mucinous tumor. It is conceivable that benign MLPs may have ability to differentiate to lineage-specific mucinous lesions, and, as such, they may serve as a possible new origin of some ovarian mucinous neoplasms; in particular, Pax8-positive tumors. The current case provides additional evidence to support this theory. MDPI 2022-08-05 /pmc/articles/PMC9406890/ /pubmed/36010251 http://dx.doi.org/10.3390/diagnostics12081901 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Zhang, Jie
Dong, Yuling
Zhou, Xiaoqiu
Finkelman, Brian S.
Xing, Deyin
Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
title Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
title_full Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
title_fullStr Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
title_full_unstemmed Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
title_short Mucinous Borderline Tumor Associated with Mesonephric-like Proliferation: Further Evidence for a Possible New Origin of Ovarian Mucinous Neoplasms
title_sort mucinous borderline tumor associated with mesonephric-like proliferation: further evidence for a possible new origin of ovarian mucinous neoplasms
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406890/
https://www.ncbi.nlm.nih.gov/pubmed/36010251
http://dx.doi.org/10.3390/diagnostics12081901
work_keys_str_mv AT zhangjie mucinousborderlinetumorassociatedwithmesonephriclikeproliferationfurtherevidenceforapossibleneworiginofovarianmucinousneoplasms
AT dongyuling mucinousborderlinetumorassociatedwithmesonephriclikeproliferationfurtherevidenceforapossibleneworiginofovarianmucinousneoplasms
AT zhouxiaoqiu mucinousborderlinetumorassociatedwithmesonephriclikeproliferationfurtherevidenceforapossibleneworiginofovarianmucinousneoplasms
AT finkelmanbrians mucinousborderlinetumorassociatedwithmesonephriclikeproliferationfurtherevidenceforapossibleneworiginofovarianmucinousneoplasms
AT xingdeyin mucinousborderlinetumorassociatedwithmesonephriclikeproliferationfurtherevidenceforapossibleneworiginofovarianmucinousneoplasms