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Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study

(1) Background: Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disorder, associated with long-term neurological sequelae. The aim of this study was to retrospectively evaluate the most commonly encountered perinatal risk factors for this disease in a cohort of newborns from Romania. (2) Me...

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Autores principales: Filip, Catalina, Zonda, Gabriela Ildiko, Vasilache, Ingrid-Andrada, Scripcariu, Ioana Sadiye, Vicoveanu, Petronela, Dima, Vlad, Socolov, Demetra, Paduraru, Luminita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406898/
https://www.ncbi.nlm.nih.gov/pubmed/36010072
http://dx.doi.org/10.3390/children9081182
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author Filip, Catalina
Zonda, Gabriela Ildiko
Vasilache, Ingrid-Andrada
Scripcariu, Ioana Sadiye
Vicoveanu, Petronela
Dima, Vlad
Socolov, Demetra
Paduraru, Luminita
author_facet Filip, Catalina
Zonda, Gabriela Ildiko
Vasilache, Ingrid-Andrada
Scripcariu, Ioana Sadiye
Vicoveanu, Petronela
Dima, Vlad
Socolov, Demetra
Paduraru, Luminita
author_sort Filip, Catalina
collection PubMed
description (1) Background: Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disorder, associated with long-term neurological sequelae. The aim of this study was to retrospectively evaluate the most commonly encountered perinatal risk factors for this disease in a cohort of newborns from Romania. (2) Methods: The medical records of neonatal CSVT patients treated between January 2017 and December 2021 were descriptively assessed. (3) Results: The study included nine neonates, five males (55.56%) and four females (44.44%), who were born at term. The most commonly presented clinical manifestations were feeding difficulties, lethargy, respiratory distress, loss of consciousness, and seizures. Maternal-inherited thrombophilia, male sex, complicated delivery, perinatal asphyxia, and mechanical ventilation were frequently identified as potential risk factors for developing CSVT. The lesions were more frequently localized in the superior sagittal sinus (n = 7; 77.78%), followed by the transverse (n = 4; 44.44%), sigmoid (n = 2; 22.22%), and cavernous (n = 1; 11.11%) sinuses. Low-molecular-weight heparin was administered to all patients, and two of them died from thrombotic complications. (4) Conclusions: Recognition of potential risk factors and a prompt diagnosis of neonatal CSVT could lead to better patient management and to a reduction of severe complications.
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spelling pubmed-94068982022-08-26 Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study Filip, Catalina Zonda, Gabriela Ildiko Vasilache, Ingrid-Andrada Scripcariu, Ioana Sadiye Vicoveanu, Petronela Dima, Vlad Socolov, Demetra Paduraru, Luminita Children (Basel) Article (1) Background: Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disorder, associated with long-term neurological sequelae. The aim of this study was to retrospectively evaluate the most commonly encountered perinatal risk factors for this disease in a cohort of newborns from Romania. (2) Methods: The medical records of neonatal CSVT patients treated between January 2017 and December 2021 were descriptively assessed. (3) Results: The study included nine neonates, five males (55.56%) and four females (44.44%), who were born at term. The most commonly presented clinical manifestations were feeding difficulties, lethargy, respiratory distress, loss of consciousness, and seizures. Maternal-inherited thrombophilia, male sex, complicated delivery, perinatal asphyxia, and mechanical ventilation were frequently identified as potential risk factors for developing CSVT. The lesions were more frequently localized in the superior sagittal sinus (n = 7; 77.78%), followed by the transverse (n = 4; 44.44%), sigmoid (n = 2; 22.22%), and cavernous (n = 1; 11.11%) sinuses. Low-molecular-weight heparin was administered to all patients, and two of them died from thrombotic complications. (4) Conclusions: Recognition of potential risk factors and a prompt diagnosis of neonatal CSVT could lead to better patient management and to a reduction of severe complications. MDPI 2022-08-07 /pmc/articles/PMC9406898/ /pubmed/36010072 http://dx.doi.org/10.3390/children9081182 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Filip, Catalina
Zonda, Gabriela Ildiko
Vasilache, Ingrid-Andrada
Scripcariu, Ioana Sadiye
Vicoveanu, Petronela
Dima, Vlad
Socolov, Demetra
Paduraru, Luminita
Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
title Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
title_full Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
title_fullStr Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
title_full_unstemmed Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
title_short Neonatal Cerebral Sinovenous Thrombosis and the Main Perinatal Risk Factors—A Retrospective Unicentric Study
title_sort neonatal cerebral sinovenous thrombosis and the main perinatal risk factors—a retrospective unicentric study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406898/
https://www.ncbi.nlm.nih.gov/pubmed/36010072
http://dx.doi.org/10.3390/children9081182
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