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Vaginal Microbiome in Reproductive Medicine

The human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has eme...

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Autores principales: Günther, Veronika, Allahqoli, Leila, Watrowski, Rafal, Maass, Nicolai, Ackermann, Johannes, von Otte, Sören, Alkatout, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406911/
https://www.ncbi.nlm.nih.gov/pubmed/36010298
http://dx.doi.org/10.3390/diagnostics12081948
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author Günther, Veronika
Allahqoli, Leila
Watrowski, Rafal
Maass, Nicolai
Ackermann, Johannes
von Otte, Sören
Alkatout, Ibrahim
author_facet Günther, Veronika
Allahqoli, Leila
Watrowski, Rafal
Maass, Nicolai
Ackermann, Johannes
von Otte, Sören
Alkatout, Ibrahim
author_sort Günther, Veronika
collection PubMed
description The human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has emerged as a major point of focus in science, reproductive medicine has developed into a subject of avid interest, particularly with regard to causal research and treatment options for implantation failure. Thus, the vaginal microbiome is discussed as a factor influencing infertility and a promising target for treatment options. The present review provides an overview of current research concerning the impact of the vaginal microbiome on the outcome of reproductive measures. A non-Lactobacillus-dominated microbiome was shown to be associated with dysbiosis, possibly even bacterial vaginosis. This imbalance has a negative impact on implantation rates in assisted reproductive technologies and may also be responsible for habitual abortions. Screening of the microbiome in conjunction with antibiotic and/or probiotic treatment appears to be one way of improving pregnancy outcomes.
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spelling pubmed-94069112022-08-26 Vaginal Microbiome in Reproductive Medicine Günther, Veronika Allahqoli, Leila Watrowski, Rafal Maass, Nicolai Ackermann, Johannes von Otte, Sören Alkatout, Ibrahim Diagnostics (Basel) Review The human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has emerged as a major point of focus in science, reproductive medicine has developed into a subject of avid interest, particularly with regard to causal research and treatment options for implantation failure. Thus, the vaginal microbiome is discussed as a factor influencing infertility and a promising target for treatment options. The present review provides an overview of current research concerning the impact of the vaginal microbiome on the outcome of reproductive measures. A non-Lactobacillus-dominated microbiome was shown to be associated with dysbiosis, possibly even bacterial vaginosis. This imbalance has a negative impact on implantation rates in assisted reproductive technologies and may also be responsible for habitual abortions. Screening of the microbiome in conjunction with antibiotic and/or probiotic treatment appears to be one way of improving pregnancy outcomes. MDPI 2022-08-12 /pmc/articles/PMC9406911/ /pubmed/36010298 http://dx.doi.org/10.3390/diagnostics12081948 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Günther, Veronika
Allahqoli, Leila
Watrowski, Rafal
Maass, Nicolai
Ackermann, Johannes
von Otte, Sören
Alkatout, Ibrahim
Vaginal Microbiome in Reproductive Medicine
title Vaginal Microbiome in Reproductive Medicine
title_full Vaginal Microbiome in Reproductive Medicine
title_fullStr Vaginal Microbiome in Reproductive Medicine
title_full_unstemmed Vaginal Microbiome in Reproductive Medicine
title_short Vaginal Microbiome in Reproductive Medicine
title_sort vaginal microbiome in reproductive medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406911/
https://www.ncbi.nlm.nih.gov/pubmed/36010298
http://dx.doi.org/10.3390/diagnostics12081948
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