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Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential r...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406922/ https://www.ncbi.nlm.nih.gov/pubmed/36010321 http://dx.doi.org/10.3390/diagnostics12081971 |
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author | Minieri, Marilena Di Lecce, Vito N. Lia, Maria Stella Maurici, Massimo Leonardis, Francesca Longo, Susanna Colangeli, Luca Paganelli, Carla Levantesi, Stefania Terrinoni, Alessandro Malagnino, Vincenzo Brunetti, Domenico J. Giovannelli, Alfredo Pieri, Massimo Ciotti, Marco D’Agostini, Cartesio Gabriele, Mariachiara Bernardini, Sergio Legramante, Jacopo M. |
author_facet | Minieri, Marilena Di Lecce, Vito N. Lia, Maria Stella Maurici, Massimo Leonardis, Francesca Longo, Susanna Colangeli, Luca Paganelli, Carla Levantesi, Stefania Terrinoni, Alessandro Malagnino, Vincenzo Brunetti, Domenico J. Giovannelli, Alfredo Pieri, Massimo Ciotti, Marco D’Agostini, Cartesio Gabriele, Mariachiara Bernardini, Sergio Legramante, Jacopo M. |
author_sort | Minieri, Marilena |
collection | PubMed |
description | In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential role of the new biomarker mid-regional proadrenomedullin (MR-proADM) in stratifying the in-hospital mortality risk of COVID-19 patients at the triage. A further goal of the present study is to evaluate whether MR-proADM together with other biochemical markers could play a key role in assessing the correct care level of these patients. Data from 321 consecutive patients admitted to the triage of the ED with a COVID-19 infection were analyzed. Epidemiological; demographic; clinical; laboratory; and outcome data were assessed. All the biomarkers analyzed showed an important role in predicting mortality. In particular, an increase of MR-proADM level at ED admission was independently associated with a threefold higher risk of IMV. MR-proADM showed greater ROC curves and AUC when compared to other laboratory biomarkers for the primary endpoint such as in-hospital mortality, except for CRP. This study shows that MR-proADM seems to be particularly effective for early predicting mortality and the need of ventilation in COVID-19 patients admitted to the ED. |
format | Online Article Text |
id | pubmed-9406922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94069222022-08-26 Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department Minieri, Marilena Di Lecce, Vito N. Lia, Maria Stella Maurici, Massimo Leonardis, Francesca Longo, Susanna Colangeli, Luca Paganelli, Carla Levantesi, Stefania Terrinoni, Alessandro Malagnino, Vincenzo Brunetti, Domenico J. Giovannelli, Alfredo Pieri, Massimo Ciotti, Marco D’Agostini, Cartesio Gabriele, Mariachiara Bernardini, Sergio Legramante, Jacopo M. Diagnostics (Basel) Article In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential role of the new biomarker mid-regional proadrenomedullin (MR-proADM) in stratifying the in-hospital mortality risk of COVID-19 patients at the triage. A further goal of the present study is to evaluate whether MR-proADM together with other biochemical markers could play a key role in assessing the correct care level of these patients. Data from 321 consecutive patients admitted to the triage of the ED with a COVID-19 infection were analyzed. Epidemiological; demographic; clinical; laboratory; and outcome data were assessed. All the biomarkers analyzed showed an important role in predicting mortality. In particular, an increase of MR-proADM level at ED admission was independently associated with a threefold higher risk of IMV. MR-proADM showed greater ROC curves and AUC when compared to other laboratory biomarkers for the primary endpoint such as in-hospital mortality, except for CRP. This study shows that MR-proADM seems to be particularly effective for early predicting mortality and the need of ventilation in COVID-19 patients admitted to the ED. MDPI 2022-08-15 /pmc/articles/PMC9406922/ /pubmed/36010321 http://dx.doi.org/10.3390/diagnostics12081971 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Minieri, Marilena Di Lecce, Vito N. Lia, Maria Stella Maurici, Massimo Leonardis, Francesca Longo, Susanna Colangeli, Luca Paganelli, Carla Levantesi, Stefania Terrinoni, Alessandro Malagnino, Vincenzo Brunetti, Domenico J. Giovannelli, Alfredo Pieri, Massimo Ciotti, Marco D’Agostini, Cartesio Gabriele, Mariachiara Bernardini, Sergio Legramante, Jacopo M. Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department |
title | Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department |
title_full | Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department |
title_fullStr | Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department |
title_full_unstemmed | Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department |
title_short | Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department |
title_sort | predictive value of mr-proadm in the risk stratification and in the adequate care setting of covid-19 patients assessed at the triage of the emergency department |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406922/ https://www.ncbi.nlm.nih.gov/pubmed/36010321 http://dx.doi.org/10.3390/diagnostics12081971 |
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