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Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department

In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential r...

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Autores principales: Minieri, Marilena, Di Lecce, Vito N., Lia, Maria Stella, Maurici, Massimo, Leonardis, Francesca, Longo, Susanna, Colangeli, Luca, Paganelli, Carla, Levantesi, Stefania, Terrinoni, Alessandro, Malagnino, Vincenzo, Brunetti, Domenico J., Giovannelli, Alfredo, Pieri, Massimo, Ciotti, Marco, D’Agostini, Cartesio, Gabriele, Mariachiara, Bernardini, Sergio, Legramante, Jacopo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406922/
https://www.ncbi.nlm.nih.gov/pubmed/36010321
http://dx.doi.org/10.3390/diagnostics12081971
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author Minieri, Marilena
Di Lecce, Vito N.
Lia, Maria Stella
Maurici, Massimo
Leonardis, Francesca
Longo, Susanna
Colangeli, Luca
Paganelli, Carla
Levantesi, Stefania
Terrinoni, Alessandro
Malagnino, Vincenzo
Brunetti, Domenico J.
Giovannelli, Alfredo
Pieri, Massimo
Ciotti, Marco
D’Agostini, Cartesio
Gabriele, Mariachiara
Bernardini, Sergio
Legramante, Jacopo M.
author_facet Minieri, Marilena
Di Lecce, Vito N.
Lia, Maria Stella
Maurici, Massimo
Leonardis, Francesca
Longo, Susanna
Colangeli, Luca
Paganelli, Carla
Levantesi, Stefania
Terrinoni, Alessandro
Malagnino, Vincenzo
Brunetti, Domenico J.
Giovannelli, Alfredo
Pieri, Massimo
Ciotti, Marco
D’Agostini, Cartesio
Gabriele, Mariachiara
Bernardini, Sergio
Legramante, Jacopo M.
author_sort Minieri, Marilena
collection PubMed
description In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential role of the new biomarker mid-regional proadrenomedullin (MR-proADM) in stratifying the in-hospital mortality risk of COVID-19 patients at the triage. A further goal of the present study is to evaluate whether MR-proADM together with other biochemical markers could play a key role in assessing the correct care level of these patients. Data from 321 consecutive patients admitted to the triage of the ED with a COVID-19 infection were analyzed. Epidemiological; demographic; clinical; laboratory; and outcome data were assessed. All the biomarkers analyzed showed an important role in predicting mortality. In particular, an increase of MR-proADM level at ED admission was independently associated with a threefold higher risk of IMV. MR-proADM showed greater ROC curves and AUC when compared to other laboratory biomarkers for the primary endpoint such as in-hospital mortality, except for CRP. This study shows that MR-proADM seems to be particularly effective for early predicting mortality and the need of ventilation in COVID-19 patients admitted to the ED.
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spelling pubmed-94069222022-08-26 Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department Minieri, Marilena Di Lecce, Vito N. Lia, Maria Stella Maurici, Massimo Leonardis, Francesca Longo, Susanna Colangeli, Luca Paganelli, Carla Levantesi, Stefania Terrinoni, Alessandro Malagnino, Vincenzo Brunetti, Domenico J. Giovannelli, Alfredo Pieri, Massimo Ciotti, Marco D’Agostini, Cartesio Gabriele, Mariachiara Bernardini, Sergio Legramante, Jacopo M. Diagnostics (Basel) Article In the past two pandemic years, Emergency Departments (ED) have been overrun with COVID-19-suspicious patients. Some data on the role played by laboratory biomarkers in the early risk stratification of COVID-19 patients have been recently published. The aim of this study is to assess the potential role of the new biomarker mid-regional proadrenomedullin (MR-proADM) in stratifying the in-hospital mortality risk of COVID-19 patients at the triage. A further goal of the present study is to evaluate whether MR-proADM together with other biochemical markers could play a key role in assessing the correct care level of these patients. Data from 321 consecutive patients admitted to the triage of the ED with a COVID-19 infection were analyzed. Epidemiological; demographic; clinical; laboratory; and outcome data were assessed. All the biomarkers analyzed showed an important role in predicting mortality. In particular, an increase of MR-proADM level at ED admission was independently associated with a threefold higher risk of IMV. MR-proADM showed greater ROC curves and AUC when compared to other laboratory biomarkers for the primary endpoint such as in-hospital mortality, except for CRP. This study shows that MR-proADM seems to be particularly effective for early predicting mortality and the need of ventilation in COVID-19 patients admitted to the ED. MDPI 2022-08-15 /pmc/articles/PMC9406922/ /pubmed/36010321 http://dx.doi.org/10.3390/diagnostics12081971 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Minieri, Marilena
Di Lecce, Vito N.
Lia, Maria Stella
Maurici, Massimo
Leonardis, Francesca
Longo, Susanna
Colangeli, Luca
Paganelli, Carla
Levantesi, Stefania
Terrinoni, Alessandro
Malagnino, Vincenzo
Brunetti, Domenico J.
Giovannelli, Alfredo
Pieri, Massimo
Ciotti, Marco
D’Agostini, Cartesio
Gabriele, Mariachiara
Bernardini, Sergio
Legramante, Jacopo M.
Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
title Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
title_full Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
title_fullStr Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
title_full_unstemmed Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
title_short Predictive Value of MR-proADM in the Risk Stratification and in the Adequate Care Setting of COVID-19 Patients Assessed at the Triage of the Emergency Department
title_sort predictive value of mr-proadm in the risk stratification and in the adequate care setting of covid-19 patients assessed at the triage of the emergency department
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406922/
https://www.ncbi.nlm.nih.gov/pubmed/36010321
http://dx.doi.org/10.3390/diagnostics12081971
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