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Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma
Papillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and ty...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406930/ https://www.ncbi.nlm.nih.gov/pubmed/36010254 http://dx.doi.org/10.3390/diagnostics12081904 |
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author | Harich, Octavia Oana Olteanu, Gheorghe-Emilian Mihai, Ioana Maria Benta, Marius Isabella, Gavriliuc Oana Virgil, Paunescu Bojin, Florina Maria |
author_facet | Harich, Octavia Oana Olteanu, Gheorghe-Emilian Mihai, Ioana Maria Benta, Marius Isabella, Gavriliuc Oana Virgil, Paunescu Bojin, Florina Maria |
author_sort | Harich, Octavia Oana |
collection | PubMed |
description | Papillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and type II PRCC, which can show multiple types of histologies and is more aggressive. The WHO 2022 classification eliminated the subcategorization of PRCC. Here, we present a histopathological case study with a 4-year follow-up diagnosed in 2018 as type I PRCC (WHO 2016) with intra-pyelocalyceal growth pattern in a 59-year-old male patient with a history of Type II diabetes mellitus, left-sided renal–ureteral lithiasis, and benign hypertrophy of the prostate. Microscopically the tumor was composed of small cuboidal cells with inconspicuous nucleoli, arranged on a single layer of tubulo-papillary cores, and scant, foamy macrophages. The tumor had a non-infiltrative, expansive pyelocalyceal growth pattern. Immunohistochemically (IHC), the tumor cells were CK7-intense and diffusely positive, and stained granular for AMACR. Next-generation sequencing (NGS) was performed for the tumor and the normal adjacent tissue for in-depth pathological characterization. To our knowledge, this is the first reported case where a PRCC displays this unique intra-pyelocalyceal growth pattern, mimicking a urothelial cell carcinoma of the renal pelvis system. |
format | Online Article Text |
id | pubmed-9406930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94069302022-08-26 Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma Harich, Octavia Oana Olteanu, Gheorghe-Emilian Mihai, Ioana Maria Benta, Marius Isabella, Gavriliuc Oana Virgil, Paunescu Bojin, Florina Maria Diagnostics (Basel) Case Report Papillary renal cell carcinoma (PRCC) is defined by the WHO 2022 classification as a malignant tumor derived from the renal tubular epithelium. However, the WHO 2016 classification subdivided PRCC into two types, with type 1 PRCC showing papillae covered by a single layer of neoplastic cells, and type II PRCC, which can show multiple types of histologies and is more aggressive. The WHO 2022 classification eliminated the subcategorization of PRCC. Here, we present a histopathological case study with a 4-year follow-up diagnosed in 2018 as type I PRCC (WHO 2016) with intra-pyelocalyceal growth pattern in a 59-year-old male patient with a history of Type II diabetes mellitus, left-sided renal–ureteral lithiasis, and benign hypertrophy of the prostate. Microscopically the tumor was composed of small cuboidal cells with inconspicuous nucleoli, arranged on a single layer of tubulo-papillary cores, and scant, foamy macrophages. The tumor had a non-infiltrative, expansive pyelocalyceal growth pattern. Immunohistochemically (IHC), the tumor cells were CK7-intense and diffusely positive, and stained granular for AMACR. Next-generation sequencing (NGS) was performed for the tumor and the normal adjacent tissue for in-depth pathological characterization. To our knowledge, this is the first reported case where a PRCC displays this unique intra-pyelocalyceal growth pattern, mimicking a urothelial cell carcinoma of the renal pelvis system. MDPI 2022-08-06 /pmc/articles/PMC9406930/ /pubmed/36010254 http://dx.doi.org/10.3390/diagnostics12081904 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Harich, Octavia Oana Olteanu, Gheorghe-Emilian Mihai, Ioana Maria Benta, Marius Isabella, Gavriliuc Oana Virgil, Paunescu Bojin, Florina Maria Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma |
title | Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma |
title_full | Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma |
title_fullStr | Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma |
title_full_unstemmed | Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma |
title_short | Unique Growth Pattern Presentation of a Papillary Renal Cell Carcinoma |
title_sort | unique growth pattern presentation of a papillary renal cell carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406930/ https://www.ncbi.nlm.nih.gov/pubmed/36010254 http://dx.doi.org/10.3390/diagnostics12081904 |
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