Cargando…
In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
(1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital or...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406976/ https://www.ncbi.nlm.nih.gov/pubmed/36010316 http://dx.doi.org/10.3390/diagnostics12081966 |
_version_ | 1784774253062651904 |
---|---|
author | Adam, Răzvan Antoniac, Iulian Negoiță, Silviu Moldovan, Cosmin Rusu, Elena Orban, Carmen Tudorache, Sorin Hârșovescu, Tudor |
author_facet | Adam, Răzvan Antoniac, Iulian Negoiță, Silviu Moldovan, Cosmin Rusu, Elena Orban, Carmen Tudorache, Sorin Hârșovescu, Tudor |
author_sort | Adam, Răzvan |
collection | PubMed |
description | (1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital organs, interference with coagulation processes, and trophocyte viability impairment can occur. (2) Methods: We conducted an in vivo study on ten rabbit cases, in two groups; group one, consisting of six cases, received cylindrical implants of Mg–1Ca alloy in tibial intramedullary bone tissue. Group two, consisting of four cases, received Mg–1Ca parallelepiped implants, in the thigh muscular tissue. We recorded and compared weight (preoperatively and at 2, 4, and 6 weeks postoperatively), complete blood count, serum electrolytes, liver and kidney functional markers, and coagulation parameters, prior to and at 6 weeks after surgery. Local evolution was assessed radiologically and with tissue biopsies with complete pathology analysis. (3) Results: All biological markers and clinical evolution were favorable, showing good integration of the implants with none of the local or systemic signs of degradation. (4) Conclusions: Our study shows that the clinical use of Mg–1Ca bioresorbable alloys can be safe as none of the cited local or systemic complications have been identified. |
format | Online Article Text |
id | pubmed-9406976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94069762022-08-26 In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants Adam, Răzvan Antoniac, Iulian Negoiță, Silviu Moldovan, Cosmin Rusu, Elena Orban, Carmen Tudorache, Sorin Hârșovescu, Tudor Diagnostics (Basel) Article (1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital organs, interference with coagulation processes, and trophocyte viability impairment can occur. (2) Methods: We conducted an in vivo study on ten rabbit cases, in two groups; group one, consisting of six cases, received cylindrical implants of Mg–1Ca alloy in tibial intramedullary bone tissue. Group two, consisting of four cases, received Mg–1Ca parallelepiped implants, in the thigh muscular tissue. We recorded and compared weight (preoperatively and at 2, 4, and 6 weeks postoperatively), complete blood count, serum electrolytes, liver and kidney functional markers, and coagulation parameters, prior to and at 6 weeks after surgery. Local evolution was assessed radiologically and with tissue biopsies with complete pathology analysis. (3) Results: All biological markers and clinical evolution were favorable, showing good integration of the implants with none of the local or systemic signs of degradation. (4) Conclusions: Our study shows that the clinical use of Mg–1Ca bioresorbable alloys can be safe as none of the cited local or systemic complications have been identified. MDPI 2022-08-14 /pmc/articles/PMC9406976/ /pubmed/36010316 http://dx.doi.org/10.3390/diagnostics12081966 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Adam, Răzvan Antoniac, Iulian Negoiță, Silviu Moldovan, Cosmin Rusu, Elena Orban, Carmen Tudorache, Sorin Hârșovescu, Tudor In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants |
title | In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants |
title_full | In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants |
title_fullStr | In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants |
title_full_unstemmed | In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants |
title_short | In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants |
title_sort | in vivo study of local and systemic responses to clinical use of mg–1ca bioresorbable orthopedic implants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406976/ https://www.ncbi.nlm.nih.gov/pubmed/36010316 http://dx.doi.org/10.3390/diagnostics12081966 |
work_keys_str_mv | AT adamrazvan invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT antoniaciulian invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT negoitasilviu invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT moldovancosmin invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT rusuelena invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT orbancarmen invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT tudorachesorin invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants AT harsovescutudor invivostudyoflocalandsystemicresponsestoclinicaluseofmg1cabioresorbableorthopedicimplants |