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In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants

(1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital or...

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Autores principales: Adam, Răzvan, Antoniac, Iulian, Negoiță, Silviu, Moldovan, Cosmin, Rusu, Elena, Orban, Carmen, Tudorache, Sorin, Hârșovescu, Tudor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406976/
https://www.ncbi.nlm.nih.gov/pubmed/36010316
http://dx.doi.org/10.3390/diagnostics12081966
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author Adam, Răzvan
Antoniac, Iulian
Negoiță, Silviu
Moldovan, Cosmin
Rusu, Elena
Orban, Carmen
Tudorache, Sorin
Hârșovescu, Tudor
author_facet Adam, Răzvan
Antoniac, Iulian
Negoiță, Silviu
Moldovan, Cosmin
Rusu, Elena
Orban, Carmen
Tudorache, Sorin
Hârșovescu, Tudor
author_sort Adam, Răzvan
collection PubMed
description (1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital organs, interference with coagulation processes, and trophocyte viability impairment can occur. (2) Methods: We conducted an in vivo study on ten rabbit cases, in two groups; group one, consisting of six cases, received cylindrical implants of Mg–1Ca alloy in tibial intramedullary bone tissue. Group two, consisting of four cases, received Mg–1Ca parallelepiped implants, in the thigh muscular tissue. We recorded and compared weight (preoperatively and at 2, 4, and 6 weeks postoperatively), complete blood count, serum electrolytes, liver and kidney functional markers, and coagulation parameters, prior to and at 6 weeks after surgery. Local evolution was assessed radiologically and with tissue biopsies with complete pathology analysis. (3) Results: All biological markers and clinical evolution were favorable, showing good integration of the implants with none of the local or systemic signs of degradation. (4) Conclusions: Our study shows that the clinical use of Mg–1Ca bioresorbable alloys can be safe as none of the cited local or systemic complications have been identified.
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spelling pubmed-94069762022-08-26 In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants Adam, Răzvan Antoniac, Iulian Negoiță, Silviu Moldovan, Cosmin Rusu, Elena Orban, Carmen Tudorache, Sorin Hârșovescu, Tudor Diagnostics (Basel) Article (1) Background: Resorbable Mg-based implants represent a new direction in orthopedic surgery but have some drawbacks, such as their rapid biodegradation and increased rate of corrosion. Some in vitro studies hypothesized that tissue necrosis, incision dehiscence, risk of gas embolization in vital organs, interference with coagulation processes, and trophocyte viability impairment can occur. (2) Methods: We conducted an in vivo study on ten rabbit cases, in two groups; group one, consisting of six cases, received cylindrical implants of Mg–1Ca alloy in tibial intramedullary bone tissue. Group two, consisting of four cases, received Mg–1Ca parallelepiped implants, in the thigh muscular tissue. We recorded and compared weight (preoperatively and at 2, 4, and 6 weeks postoperatively), complete blood count, serum electrolytes, liver and kidney functional markers, and coagulation parameters, prior to and at 6 weeks after surgery. Local evolution was assessed radiologically and with tissue biopsies with complete pathology analysis. (3) Results: All biological markers and clinical evolution were favorable, showing good integration of the implants with none of the local or systemic signs of degradation. (4) Conclusions: Our study shows that the clinical use of Mg–1Ca bioresorbable alloys can be safe as none of the cited local or systemic complications have been identified. MDPI 2022-08-14 /pmc/articles/PMC9406976/ /pubmed/36010316 http://dx.doi.org/10.3390/diagnostics12081966 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Adam, Răzvan
Antoniac, Iulian
Negoiță, Silviu
Moldovan, Cosmin
Rusu, Elena
Orban, Carmen
Tudorache, Sorin
Hârșovescu, Tudor
In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
title In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
title_full In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
title_fullStr In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
title_full_unstemmed In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
title_short In Vivo Study of Local and Systemic Responses to Clinical Use of Mg–1Ca Bioresorbable Orthopedic Implants
title_sort in vivo study of local and systemic responses to clinical use of mg–1ca bioresorbable orthopedic implants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406976/
https://www.ncbi.nlm.nih.gov/pubmed/36010316
http://dx.doi.org/10.3390/diagnostics12081966
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