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Administration of 3% Sodium Chloride and Local Infusion Reactions
Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to eva...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406999/ https://www.ncbi.nlm.nih.gov/pubmed/36010135 http://dx.doi.org/10.3390/children9081245 |
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author | Moritz, Michael L. Ayus, Juan C. Nelson, Joel B. |
author_facet | Moritz, Michael L. Ayus, Juan C. Nelson, Joel B. |
author_sort | Moritz, Michael L. |
collection | PubMed |
description | Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year period throughout a large healthcare system. A query was conducted through the Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system, which consists of 40 hospitals with 8400 licensed beds, over a 10-year time period from 14 May 2010 to 14 May 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues, and IV solutions. There were 23,714 non-chemotherapeutic and non-contrast-associated intravenous events, of which 4678 (19.7%) were at UPMC Children’s Hospital. A total of 2306 patients received 3% NaCl, of whom 836 (35.8%) were at UPMC Children’s Hospital. There were no reported local infusion reactions with 3% NaCl. There were no reported local infusion reaction events associated with 3% NaCl in a large healthcare system over a 10-year period. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter. |
format | Online Article Text |
id | pubmed-9406999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94069992022-08-26 Administration of 3% Sodium Chloride and Local Infusion Reactions Moritz, Michael L. Ayus, Juan C. Nelson, Joel B. Children (Basel) Article Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year period throughout a large healthcare system. A query was conducted through the Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system, which consists of 40 hospitals with 8400 licensed beds, over a 10-year time period from 14 May 2010 to 14 May 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues, and IV solutions. There were 23,714 non-chemotherapeutic and non-contrast-associated intravenous events, of which 4678 (19.7%) were at UPMC Children’s Hospital. A total of 2306 patients received 3% NaCl, of whom 836 (35.8%) were at UPMC Children’s Hospital. There were no reported local infusion reactions with 3% NaCl. There were no reported local infusion reaction events associated with 3% NaCl in a large healthcare system over a 10-year period. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter. MDPI 2022-08-18 /pmc/articles/PMC9406999/ /pubmed/36010135 http://dx.doi.org/10.3390/children9081245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moritz, Michael L. Ayus, Juan C. Nelson, Joel B. Administration of 3% Sodium Chloride and Local Infusion Reactions |
title | Administration of 3% Sodium Chloride and Local Infusion Reactions |
title_full | Administration of 3% Sodium Chloride and Local Infusion Reactions |
title_fullStr | Administration of 3% Sodium Chloride and Local Infusion Reactions |
title_full_unstemmed | Administration of 3% Sodium Chloride and Local Infusion Reactions |
title_short | Administration of 3% Sodium Chloride and Local Infusion Reactions |
title_sort | administration of 3% sodium chloride and local infusion reactions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406999/ https://www.ncbi.nlm.nih.gov/pubmed/36010135 http://dx.doi.org/10.3390/children9081245 |
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