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Administration of 3% Sodium Chloride and Local Infusion Reactions

Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to eva...

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Detalles Bibliográficos
Autores principales: Moritz, Michael L., Ayus, Juan C., Nelson, Joel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406999/
https://www.ncbi.nlm.nih.gov/pubmed/36010135
http://dx.doi.org/10.3390/children9081245
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author Moritz, Michael L.
Ayus, Juan C.
Nelson, Joel B.
author_facet Moritz, Michael L.
Ayus, Juan C.
Nelson, Joel B.
author_sort Moritz, Michael L.
collection PubMed
description Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year period throughout a large healthcare system. A query was conducted through the Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system, which consists of 40 hospitals with 8400 licensed beds, over a 10-year time period from 14 May 2010 to 14 May 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues, and IV solutions. There were 23,714 non-chemotherapeutic and non-contrast-associated intravenous events, of which 4678 (19.7%) were at UPMC Children’s Hospital. A total of 2306 patients received 3% NaCl, of whom 836 (35.8%) were at UPMC Children’s Hospital. There were no reported local infusion reactions with 3% NaCl. There were no reported local infusion reaction events associated with 3% NaCl in a large healthcare system over a 10-year period. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter.
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spelling pubmed-94069992022-08-26 Administration of 3% Sodium Chloride and Local Infusion Reactions Moritz, Michael L. Ayus, Juan C. Nelson, Joel B. Children (Basel) Article Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent used to treat hyponatremic encephalopathy or other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of local infusion reactions when administered through a peripheral vein. We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year period throughout a large healthcare system. A query was conducted through the Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system, which consists of 40 hospitals with 8400 licensed beds, over a 10-year time period from 14 May 2010 to 14 May 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues, and IV solutions. There were 23,714 non-chemotherapeutic and non-contrast-associated intravenous events, of which 4678 (19.7%) were at UPMC Children’s Hospital. A total of 2306 patients received 3% NaCl, of whom 836 (35.8%) were at UPMC Children’s Hospital. There were no reported local infusion reactions with 3% NaCl. There were no reported local infusion reaction events associated with 3% NaCl in a large healthcare system over a 10-year period. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter. MDPI 2022-08-18 /pmc/articles/PMC9406999/ /pubmed/36010135 http://dx.doi.org/10.3390/children9081245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moritz, Michael L.
Ayus, Juan C.
Nelson, Joel B.
Administration of 3% Sodium Chloride and Local Infusion Reactions
title Administration of 3% Sodium Chloride and Local Infusion Reactions
title_full Administration of 3% Sodium Chloride and Local Infusion Reactions
title_fullStr Administration of 3% Sodium Chloride and Local Infusion Reactions
title_full_unstemmed Administration of 3% Sodium Chloride and Local Infusion Reactions
title_short Administration of 3% Sodium Chloride and Local Infusion Reactions
title_sort administration of 3% sodium chloride and local infusion reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406999/
https://www.ncbi.nlm.nih.gov/pubmed/36010135
http://dx.doi.org/10.3390/children9081245
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