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Optical Monitoring in Neonatal Seizures

Background: Neonatal seizures remain a significant cause of morbidity and mortality worldwide. The past decade has resulted in substantial progress in seizure detection and understanding the impact seizures have on the developing brain. Optical monitoring such as cerebral near-infrared spectroscopy...

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Autores principales: Howard, Rachel, Li, Runci, Harvey-Jones, Kelly, Verma, Vinita, Lange, Frédéric, Boylan, Geraldine, Tachtsidis, Ilias, Mitra, Subhabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407001/
https://www.ncbi.nlm.nih.gov/pubmed/36010678
http://dx.doi.org/10.3390/cells11162602
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author Howard, Rachel
Li, Runci
Harvey-Jones, Kelly
Verma, Vinita
Lange, Frédéric
Boylan, Geraldine
Tachtsidis, Ilias
Mitra, Subhabrata
author_facet Howard, Rachel
Li, Runci
Harvey-Jones, Kelly
Verma, Vinita
Lange, Frédéric
Boylan, Geraldine
Tachtsidis, Ilias
Mitra, Subhabrata
author_sort Howard, Rachel
collection PubMed
description Background: Neonatal seizures remain a significant cause of morbidity and mortality worldwide. The past decade has resulted in substantial progress in seizure detection and understanding the impact seizures have on the developing brain. Optical monitoring such as cerebral near-infrared spectroscopy (NIRS) and broadband NIRS can provide non-invasive continuous real-time monitoring of the changes in brain metabolism and haemodynamics. Aim: To perform a systematic review of optical biomarkers to identify changes in cerebral haemodynamics and metabolism during the pre-ictal, ictal, and post-ictal phases of neonatal seizures. Method: A systematic search was performed in eight databases. The search combined the three broad categories: (neonates) AND (NIRS) AND (seizures) using the stepwise approach following PRISMA guidance. Results: Fifteen papers described the haemodynamic and/or metabolic changes observed with NIRS during neonatal seizures. No randomised controlled trials were identified during the search. Studies reported various changes occurring in the pre-ictal, ictal, and post-ictal phases of seizures. Conclusion: Clear changes in cerebral haemodynamics and metabolism were noted during the pre-ictal, ictal, and post-ictal phases of seizures in neonates. Further studies are necessary to determine whether NIRS-based methods can be used at the cot-side to provide clear pathophysiological data in real-time during neonatal seizures.
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spelling pubmed-94070012022-08-26 Optical Monitoring in Neonatal Seizures Howard, Rachel Li, Runci Harvey-Jones, Kelly Verma, Vinita Lange, Frédéric Boylan, Geraldine Tachtsidis, Ilias Mitra, Subhabrata Cells Systematic Review Background: Neonatal seizures remain a significant cause of morbidity and mortality worldwide. The past decade has resulted in substantial progress in seizure detection and understanding the impact seizures have on the developing brain. Optical monitoring such as cerebral near-infrared spectroscopy (NIRS) and broadband NIRS can provide non-invasive continuous real-time monitoring of the changes in brain metabolism and haemodynamics. Aim: To perform a systematic review of optical biomarkers to identify changes in cerebral haemodynamics and metabolism during the pre-ictal, ictal, and post-ictal phases of neonatal seizures. Method: A systematic search was performed in eight databases. The search combined the three broad categories: (neonates) AND (NIRS) AND (seizures) using the stepwise approach following PRISMA guidance. Results: Fifteen papers described the haemodynamic and/or metabolic changes observed with NIRS during neonatal seizures. No randomised controlled trials were identified during the search. Studies reported various changes occurring in the pre-ictal, ictal, and post-ictal phases of seizures. Conclusion: Clear changes in cerebral haemodynamics and metabolism were noted during the pre-ictal, ictal, and post-ictal phases of seizures in neonates. Further studies are necessary to determine whether NIRS-based methods can be used at the cot-side to provide clear pathophysiological data in real-time during neonatal seizures. MDPI 2022-08-21 /pmc/articles/PMC9407001/ /pubmed/36010678 http://dx.doi.org/10.3390/cells11162602 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Howard, Rachel
Li, Runci
Harvey-Jones, Kelly
Verma, Vinita
Lange, Frédéric
Boylan, Geraldine
Tachtsidis, Ilias
Mitra, Subhabrata
Optical Monitoring in Neonatal Seizures
title Optical Monitoring in Neonatal Seizures
title_full Optical Monitoring in Neonatal Seizures
title_fullStr Optical Monitoring in Neonatal Seizures
title_full_unstemmed Optical Monitoring in Neonatal Seizures
title_short Optical Monitoring in Neonatal Seizures
title_sort optical monitoring in neonatal seizures
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407001/
https://www.ncbi.nlm.nih.gov/pubmed/36010678
http://dx.doi.org/10.3390/cells11162602
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