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Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other metabolic syndrome features. Reflecting the underlying pathogenesis and the cardiometabolic disorders associated with NAFLD, the term...

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Autores principales: Nasiri-Ansari, Narjes, Androutsakos, Theodoros, Flessa, Christina-Maria, Kyrou, Ioannis, Siasos, Gerasimos, Randeva, Harpal S., Kassi, Eva, Papavassiliou, Athanasios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407007/
https://www.ncbi.nlm.nih.gov/pubmed/36010588
http://dx.doi.org/10.3390/cells11162511
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author Nasiri-Ansari, Narjes
Androutsakos, Theodoros
Flessa, Christina-Maria
Kyrou, Ioannis
Siasos, Gerasimos
Randeva, Harpal S.
Kassi, Eva
Papavassiliou, Athanasios G.
author_facet Nasiri-Ansari, Narjes
Androutsakos, Theodoros
Flessa, Christina-Maria
Kyrou, Ioannis
Siasos, Gerasimos
Randeva, Harpal S.
Kassi, Eva
Papavassiliou, Athanasios G.
author_sort Nasiri-Ansari, Narjes
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other metabolic syndrome features. Reflecting the underlying pathogenesis and the cardiometabolic disorders associated with NAFLD, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has recently been proposed. Indeed, over the past few years, growing evidence supports a strong correlation between NAFLD and increased cardiovascular disease (CVD) risk, independent of the presence of diabetes, hypertension, and obesity. This implies that NAFLD may also be directly involved in the pathogenesis of CVD. Notably, liver sinusoidal endothelial cell (LSEC) dysfunction appears to be implicated in the progression of NAFLD via numerous mechanisms, including the regulation of the inflammatory process, hepatic stellate activation, augmented vascular resistance, and the distortion of microcirculation, resulting in the progression of NAFLD. Vice versa, the liver secretes inflammatory molecules that are considered pro-atherogenic and may contribute to vascular endothelial dysfunction, resulting in atherosclerosis and CVD. In this review, we provide current evidence supporting the role of endothelial cell dysfunction in the pathogenesis of NAFLD and NAFLD-associated atherosclerosis. Endothelial cells could thus represent a “golden target” for the development of new treatment strategies for NAFLD and its comorbid CVD.
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spelling pubmed-94070072022-08-26 Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review Nasiri-Ansari, Narjes Androutsakos, Theodoros Flessa, Christina-Maria Kyrou, Ioannis Siasos, Gerasimos Randeva, Harpal S. Kassi, Eva Papavassiliou, Athanasios G. Cells Review Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other metabolic syndrome features. Reflecting the underlying pathogenesis and the cardiometabolic disorders associated with NAFLD, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has recently been proposed. Indeed, over the past few years, growing evidence supports a strong correlation between NAFLD and increased cardiovascular disease (CVD) risk, independent of the presence of diabetes, hypertension, and obesity. This implies that NAFLD may also be directly involved in the pathogenesis of CVD. Notably, liver sinusoidal endothelial cell (LSEC) dysfunction appears to be implicated in the progression of NAFLD via numerous mechanisms, including the regulation of the inflammatory process, hepatic stellate activation, augmented vascular resistance, and the distortion of microcirculation, resulting in the progression of NAFLD. Vice versa, the liver secretes inflammatory molecules that are considered pro-atherogenic and may contribute to vascular endothelial dysfunction, resulting in atherosclerosis and CVD. In this review, we provide current evidence supporting the role of endothelial cell dysfunction in the pathogenesis of NAFLD and NAFLD-associated atherosclerosis. Endothelial cells could thus represent a “golden target” for the development of new treatment strategies for NAFLD and its comorbid CVD. MDPI 2022-08-12 /pmc/articles/PMC9407007/ /pubmed/36010588 http://dx.doi.org/10.3390/cells11162511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nasiri-Ansari, Narjes
Androutsakos, Theodoros
Flessa, Christina-Maria
Kyrou, Ioannis
Siasos, Gerasimos
Randeva, Harpal S.
Kassi, Eva
Papavassiliou, Athanasios G.
Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
title Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
title_full Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
title_fullStr Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
title_full_unstemmed Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
title_short Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review
title_sort endothelial cell dysfunction and nonalcoholic fatty liver disease (nafld): a concise review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407007/
https://www.ncbi.nlm.nih.gov/pubmed/36010588
http://dx.doi.org/10.3390/cells11162511
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