The Contribution of Genetics to Muscle Disuse, Retraining, and Aging

Genetic background may partly explain differences in muscle responses to internal or external stimuli. Muscle disuse involves various degrees of skeletal muscle atrophy due to inactivity and mechanical unloading. Whether and to which extent genetic background impacts disuse atrophy and retraining in...

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Autores principales: Sirago, Giuseppe, Picca, Anna, Giacomello, Emiliana, Marzetti, Emanuele, Toniolo, Luana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407110/
https://www.ncbi.nlm.nih.gov/pubmed/36011290
http://dx.doi.org/10.3390/genes13081378
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author Sirago, Giuseppe
Picca, Anna
Giacomello, Emiliana
Marzetti, Emanuele
Toniolo, Luana
author_facet Sirago, Giuseppe
Picca, Anna
Giacomello, Emiliana
Marzetti, Emanuele
Toniolo, Luana
author_sort Sirago, Giuseppe
collection PubMed
description Genetic background may partly explain differences in muscle responses to internal or external stimuli. Muscle disuse involves various degrees of skeletal muscle atrophy due to inactivity and mechanical unloading. Whether and to which extent genetic background impacts disuse atrophy and retraining in individuals of different ages are currently unclear. Here, we provide a brief overview of relevant literature on the contribution of genetics to muscle disuse, retraining, and aging, and offer a perspective on unanswered questions on the subject that may open new venues for research.
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spelling pubmed-94071102022-08-26 The Contribution of Genetics to Muscle Disuse, Retraining, and Aging Sirago, Giuseppe Picca, Anna Giacomello, Emiliana Marzetti, Emanuele Toniolo, Luana Genes (Basel) Perspective Genetic background may partly explain differences in muscle responses to internal or external stimuli. Muscle disuse involves various degrees of skeletal muscle atrophy due to inactivity and mechanical unloading. Whether and to which extent genetic background impacts disuse atrophy and retraining in individuals of different ages are currently unclear. Here, we provide a brief overview of relevant literature on the contribution of genetics to muscle disuse, retraining, and aging, and offer a perspective on unanswered questions on the subject that may open new venues for research. MDPI 2022-08-01 /pmc/articles/PMC9407110/ /pubmed/36011290 http://dx.doi.org/10.3390/genes13081378 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Sirago, Giuseppe
Picca, Anna
Giacomello, Emiliana
Marzetti, Emanuele
Toniolo, Luana
The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
title The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
title_full The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
title_fullStr The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
title_full_unstemmed The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
title_short The Contribution of Genetics to Muscle Disuse, Retraining, and Aging
title_sort contribution of genetics to muscle disuse, retraining, and aging
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407110/
https://www.ncbi.nlm.nih.gov/pubmed/36011290
http://dx.doi.org/10.3390/genes13081378
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