Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K(+) channels for atrial fibrillation treatment

The Ca(2+)-activated SK4 K(+) channel is gated by Ca(2+)–calmodulin (CaM) and is expressed in immune cells, brain, and heart. A cryoelectron microscopy (cryo-EM) structure of the human SK4 K(+) channel recently revealed four CaM molecules per channel tetramer, where the apo CaM C-lobe and the holo C...

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Detalles Bibliográficos
Autores principales: Burg, Shira, Shapiro, Shir, Peretz, Asher, Haimov, Elvira, Redko, Boris, Yeheskel, Adva, Simhaev, Luba, Engel, Hamutal, Raveh, Avi, Ben-Bassat, Ariel, Murninkas, Michael, Polak, Rotem, Haitin, Yoni, Etzion, Yoram, Attali, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407317/
https://www.ncbi.nlm.nih.gov/pubmed/35969786
http://dx.doi.org/10.1073/pnas.2202926119

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