O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling

Sonic hedgehog (Shh) signaling plays a critical role in regulating cerebellum development by maintaining the physiological proliferation of granule neuron precursors (GNPs), and its dysregulation leads to the oncogenesis of medulloblastoma. O-GlcNAcylation (O-GlcNAc) of proteins is an emerging regul...

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Detalles Bibliográficos
Autores principales: Chen, Liping, Li, Ying, Song, Zhihong, Xue, Saisai, Liu, Fengjiao, Chang, Xin, Wu, Yan, Duan, Xiaotao, Wu, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407465/
https://www.ncbi.nlm.nih.gov/pubmed/35969743
http://dx.doi.org/10.1073/pnas.2202821119

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