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Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas
Peripheral T-cell lymphomas (PTCLs) are uncommon neoplasms derived from mature T cells or NK cells. PTCLs comprise numerous disease entities, with over 30 distinct entities listed in the latest WHO classification. They predominantly affect adults and elderly people and usually exhibit an aggressive...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407466/ https://www.ncbi.nlm.nih.gov/pubmed/36010351 http://dx.doi.org/10.3390/diagnostics12082001 |
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author | Satou, Akira Takahara, Taishi Tsuzuki, Toyonori |
author_facet | Satou, Akira Takahara, Taishi Tsuzuki, Toyonori |
author_sort | Satou, Akira |
collection | PubMed |
description | Peripheral T-cell lymphomas (PTCLs) are uncommon neoplasms derived from mature T cells or NK cells. PTCLs comprise numerous disease entities, with over 30 distinct entities listed in the latest WHO classification. They predominantly affect adults and elderly people and usually exhibit an aggressive clinical course with poor prognosis. According to their presentation, PTCLs can be divided into nodal, extranodal or cutaneous, and leukemic types. The most frequent primary sites of PTCLs are lymph nodes, with over half of cases showing nodal presentation. Nodal PTCLs include ALK-positive and ALK-negative anaplastic large cell lymphoma; nodal T-cell lymphoma with T follicular helper cell origin; and PTCL, not otherwise specified. Adult T-cell leukemia/lymphoma also frequently affects lymph nodes. Recent pathological and molecular findings in nodal PTCLs have profoundly advanced the identification of tumor signatures and the refinement of the classification. Therefore, the therapies and pathological diagnosis of nodal PTCLs are continually evolving. This paper aims to provide a summary and update of the pathological and molecular features of nodal PTCLs, which will be helpful for diagnostic practice. |
format | Online Article Text |
id | pubmed-9407466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94074662022-08-26 Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas Satou, Akira Takahara, Taishi Tsuzuki, Toyonori Diagnostics (Basel) Review Peripheral T-cell lymphomas (PTCLs) are uncommon neoplasms derived from mature T cells or NK cells. PTCLs comprise numerous disease entities, with over 30 distinct entities listed in the latest WHO classification. They predominantly affect adults and elderly people and usually exhibit an aggressive clinical course with poor prognosis. According to their presentation, PTCLs can be divided into nodal, extranodal or cutaneous, and leukemic types. The most frequent primary sites of PTCLs are lymph nodes, with over half of cases showing nodal presentation. Nodal PTCLs include ALK-positive and ALK-negative anaplastic large cell lymphoma; nodal T-cell lymphoma with T follicular helper cell origin; and PTCL, not otherwise specified. Adult T-cell leukemia/lymphoma also frequently affects lymph nodes. Recent pathological and molecular findings in nodal PTCLs have profoundly advanced the identification of tumor signatures and the refinement of the classification. Therefore, the therapies and pathological diagnosis of nodal PTCLs are continually evolving. This paper aims to provide a summary and update of the pathological and molecular features of nodal PTCLs, which will be helpful for diagnostic practice. MDPI 2022-08-18 /pmc/articles/PMC9407466/ /pubmed/36010351 http://dx.doi.org/10.3390/diagnostics12082001 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Satou, Akira Takahara, Taishi Tsuzuki, Toyonori Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas |
title | Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas |
title_full | Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas |
title_fullStr | Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas |
title_full_unstemmed | Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas |
title_short | Pathological and Molecular Features of Nodal Peripheral T-Cell Lymphomas |
title_sort | pathological and molecular features of nodal peripheral t-cell lymphomas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407466/ https://www.ncbi.nlm.nih.gov/pubmed/36010351 http://dx.doi.org/10.3390/diagnostics12082001 |
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