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Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure

Hepatitis E virus (HEV) infection in pregnant women has a high incidence of developing fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in genotype 1 HEV (HEV-1) are reportedly linked to FHF clinical cases, but experimental confirmation of the roles of these ch...

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Detalles Bibliográficos
Autores principales:	Wang, Bo, Tian, Debin, Sooryanarain, Harini, Mahsoub, Hassan M., Heffron, C. Lynn, Hassebroek, Anna M., Meng, Xiang-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407470/ https://www.ncbi.nlm.nih.gov/pubmed/35969750 http://dx.doi.org/10.1073/pnas.2207503119

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