Cargando…
Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women
The aim of this study was to explore the allelic association between genetic polymorphisms of the NF-κB pathway and the variance of clinical effects of zoledronic in postmenopausal Chinese women with osteoporosis. In the study, 110 Chinese postmenopausal women with osteoporosis were recruited. Every...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407517/ https://www.ncbi.nlm.nih.gov/pubmed/36011257 http://dx.doi.org/10.3390/genes13081343 |
_version_ | 1784774383401697280 |
---|---|
author | Wang, Wen-Jie He, Jin-Wei Fu, Wen-Zhen Wang, Chun Zhang, Zhen-Lin |
author_facet | Wang, Wen-Jie He, Jin-Wei Fu, Wen-Zhen Wang, Chun Zhang, Zhen-Lin |
author_sort | Wang, Wen-Jie |
collection | PubMed |
description | The aim of this study was to explore the allelic association between genetic polymorphisms of the NF-κB pathway and the variance of clinical effects of zoledronic in postmenopausal Chinese women with osteoporosis. In the study, 110 Chinese postmenopausal women with osteoporosis were recruited. Every patient received zoledronic once a year. BMD was measured at baseline and after one year of treatment. The 13 tagger SNPs of five genes in the NF-κB pathway were genotyped. In the study, 101 subjects completed the one-year follow-up. The ITCTG and DTCTG haplotypes, which are constituted of rs28362491, rs3774937, rs230521, rs230510 and rs4648068 of the NF-κB1 gene, were associated with improvement in BMD at L1-4 and femoral neck (p < 0.001, p = 0.008, respectively). The CGC haplotype, which is constituted of rs7119750, rs2306365 and rs11820062 of the RELA gene, was associated with improvement in BMD at total hip (p < 0.001). After Bonferroni correction, haplotypes ITCTG and CGC still showed significant association with the % change of BMD at L1-4 and total hip. Therefore, NF-κB1 and RELA gene were significantly associated with bone response to the treatment of zoledronic in postmenopausal Chinese women with osteoporosis. |
format | Online Article Text |
id | pubmed-9407517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94075172022-08-26 Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women Wang, Wen-Jie He, Jin-Wei Fu, Wen-Zhen Wang, Chun Zhang, Zhen-Lin Genes (Basel) Article The aim of this study was to explore the allelic association between genetic polymorphisms of the NF-κB pathway and the variance of clinical effects of zoledronic in postmenopausal Chinese women with osteoporosis. In the study, 110 Chinese postmenopausal women with osteoporosis were recruited. Every patient received zoledronic once a year. BMD was measured at baseline and after one year of treatment. The 13 tagger SNPs of five genes in the NF-κB pathway were genotyped. In the study, 101 subjects completed the one-year follow-up. The ITCTG and DTCTG haplotypes, which are constituted of rs28362491, rs3774937, rs230521, rs230510 and rs4648068 of the NF-κB1 gene, were associated with improvement in BMD at L1-4 and femoral neck (p < 0.001, p = 0.008, respectively). The CGC haplotype, which is constituted of rs7119750, rs2306365 and rs11820062 of the RELA gene, was associated with improvement in BMD at total hip (p < 0.001). After Bonferroni correction, haplotypes ITCTG and CGC still showed significant association with the % change of BMD at L1-4 and total hip. Therefore, NF-κB1 and RELA gene were significantly associated with bone response to the treatment of zoledronic in postmenopausal Chinese women with osteoporosis. MDPI 2022-07-27 /pmc/articles/PMC9407517/ /pubmed/36011257 http://dx.doi.org/10.3390/genes13081343 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Wen-Jie He, Jin-Wei Fu, Wen-Zhen Wang, Chun Zhang, Zhen-Lin Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women |
title | Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women |
title_full | Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women |
title_fullStr | Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women |
title_full_unstemmed | Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women |
title_short | Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women |
title_sort | genetic polymorphisms of nuclear factor-κb family affect the bone mineral density response to zoledronic acid therapy in postmenopausal chinese women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407517/ https://www.ncbi.nlm.nih.gov/pubmed/36011257 http://dx.doi.org/10.3390/genes13081343 |
work_keys_str_mv | AT wangwenjie geneticpolymorphismsofnuclearfactorkbfamilyaffectthebonemineraldensityresponsetozoledronicacidtherapyinpostmenopausalchinesewomen AT hejinwei geneticpolymorphismsofnuclearfactorkbfamilyaffectthebonemineraldensityresponsetozoledronicacidtherapyinpostmenopausalchinesewomen AT fuwenzhen geneticpolymorphismsofnuclearfactorkbfamilyaffectthebonemineraldensityresponsetozoledronicacidtherapyinpostmenopausalchinesewomen AT wangchun geneticpolymorphismsofnuclearfactorkbfamilyaffectthebonemineraldensityresponsetozoledronicacidtherapyinpostmenopausalchinesewomen AT zhangzhenlin geneticpolymorphismsofnuclearfactorkbfamilyaffectthebonemineraldensityresponsetozoledronicacidtherapyinpostmenopausalchinesewomen |