Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease

Vaso-occlusive episode (VOE) is a common and critical complication of sickle cell disease (SCD). Its pathogenesis is incompletely understood. von Willebrand factor (VWF), a multimeric plasma hemostatic protein synthesized and secreted by endothelial cells and platelets, is increased during a VOE. Ho...

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Detalles Bibliográficos
Autores principales: Shi, Huiping, Shao, Bojing, Gao, Liang, Venkatesan, Thamizhiniyan, McDaniel, John Michael, Zhou, Meixiang, McGee, Samuel, Yu, Pengchun, Ahamed, Jasimuddin, Journeycake, Janna, George, James N., Xia, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407592/
https://www.ncbi.nlm.nih.gov/pubmed/35969769
http://dx.doi.org/10.1073/pnas.2207592119

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