Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi

Glutamate-gated chloride channels (GluCls) are unique to invertebrates and are targeted by macrocyclic lactones. In this study, we cloned an AVR-14B GluCl subunit from adult Brugia malayi, a causative agent of lymphatic filariasis in humans. To elucidate this channel’s pharmacological properties, we...

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Detalles Bibliográficos
Autores principales: Choudhary, Shivani, Abongwa, Melanie, Kashyap, Sudhanva S., Verma, Saurabh, Mair, Gunnar R., Kulke, Daniel, Martin, Richard J., Robertson, Alan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407656/
https://www.ncbi.nlm.nih.gov/pubmed/35969762
http://dx.doi.org/10.1073/pnas.2111932119

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