Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders

There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci (mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to extensive linkage disequilibrium (LD) of the genome, it is challenging to identify causal genetic variations that drive...

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Detalles Bibliográficos
Autores principales: Zhou, Jiyun, Chen, Qiang, Braun, Patricia R., Perzel Mandell, Kira A., Jaffe, Andrew E., Tan, Hao Yang, Hyde, Thomas M., Kleinman, Joel E., Potash, James B., Shinozaki, Gen, Weinberger, Daniel R., Han, Shizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407663/
https://www.ncbi.nlm.nih.gov/pubmed/35969790
http://dx.doi.org/10.1073/pnas.2206069119

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