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Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8(+) T cell response

The targeted delivery of messenger RNA (mRNA) to desired organs remains a great challenge for in vivo applications of mRNA technology. For mRNA vaccines, the targeted delivery to the lymph node (LN) is predicted to reduce side effects and increase the immune response. In this study, we explored an e...

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Detalles Bibliográficos
Autores principales:	Chen, Jinjin, Ye, Zhongfeng, Huang, Changfeng, Qiu, Min, Song, Donghui, Li, Yamin, Xu, Qiaobing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407666/ https://www.ncbi.nlm.nih.gov/pubmed/35969778 http://dx.doi.org/10.1073/pnas.2207841119

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