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De novo designed protein inhibitors of amyloid aggregation and seeding

Neurodegenerative diseases are characterized by the pathologic accumulation of aggregated proteins. Known as amyloid, these fibrillar aggregates include proteins such as tau and amyloid-β (Aβ) in Alzheimer’s disease (AD) and alpha-synuclein (αSyn) in Parkinson’s disease (PD). The development and spr...

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Detalles Bibliográficos
Autores principales:	Murray, Kevin A., Hu, Carolyn J., Griner, Sarah L., Pan, Hope, Bowler, Jeannette T., Abskharon, Romany, Rosenberg, Gregory M., Cheng, Xinyi, Seidler, Paul M., Eisenberg, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407671/ https://www.ncbi.nlm.nih.gov/pubmed/35969734 http://dx.doi.org/10.1073/pnas.2206240119

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