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Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimer’s disease risk

Clusterin (CLU) is an extracellular chaperone involved in reducing amyloid beta (Aβ) toxicity and aggregation. Although previous genome-wide association studies (GWAS) have reported a potential protective effect of CLU on Alzheimer’s disease (AD) patients, how intron-located rs11136000 (CLU) affects...

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Detalles Bibliográficos
Autores principales:	Ma, Jin, Qiu, Shizheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407972/ https://www.ncbi.nlm.nih.gov/pubmed/36033622 http://dx.doi.org/10.3389/fnins.2022.926830

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