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Taccalonolides: Structure, semi-synthesis, and biological activity

Microtubules are the fundamental part of the cell cytoskeleton intimately involving in cell proliferation and are superb targets in clinical cancer therapy today. Microtubule stabilizers have become one of the effectively main agents in the last decades for the treatment of diverse cancers. Taccalon...

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Autores principales: Li, Yan, Du, Yu-Feng, Gao, Feng, Xu, Jin-Bu, Zheng, Ling-Li, Liu, Gang, Lei, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407980/
https://www.ncbi.nlm.nih.gov/pubmed/36034793
http://dx.doi.org/10.3389/fphar.2022.968061
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author Li, Yan
Du, Yu-Feng
Gao, Feng
Xu, Jin-Bu
Zheng, Ling-Li
Liu, Gang
Lei, Yu
author_facet Li, Yan
Du, Yu-Feng
Gao, Feng
Xu, Jin-Bu
Zheng, Ling-Li
Liu, Gang
Lei, Yu
author_sort Li, Yan
collection PubMed
description Microtubules are the fundamental part of the cell cytoskeleton intimately involving in cell proliferation and are superb targets in clinical cancer therapy today. Microtubule stabilizers have become one of the effectively main agents in the last decades for the treatment of diverse cancers. Taccalonolides, the highly oxygenated pentacyclic steroids isolated from the genus of Tacca, are considered a class of novel microtubule-stabilizing agents. Taccalonolides not only possess a similar microtubule-stabilizing activity as the famous drug paclitaxel but also reverse the multi-drug resistance of paclitaxel and epothilone in cellular and animal models. Taccalonolides have captured numerous attention in the field of medicinal chemistry due to their variety of structures, unique mechanism of action, and low toxicity. This review focuses on the structural diversity, semi-synthesis, modification, and pharmacological activities of taccalonolides, providing bright thoughts for the discovery of microtubule-stabilizing drugs.
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spelling pubmed-94079802022-08-26 Taccalonolides: Structure, semi-synthesis, and biological activity Li, Yan Du, Yu-Feng Gao, Feng Xu, Jin-Bu Zheng, Ling-Li Liu, Gang Lei, Yu Front Pharmacol Pharmacology Microtubules are the fundamental part of the cell cytoskeleton intimately involving in cell proliferation and are superb targets in clinical cancer therapy today. Microtubule stabilizers have become one of the effectively main agents in the last decades for the treatment of diverse cancers. Taccalonolides, the highly oxygenated pentacyclic steroids isolated from the genus of Tacca, are considered a class of novel microtubule-stabilizing agents. Taccalonolides not only possess a similar microtubule-stabilizing activity as the famous drug paclitaxel but also reverse the multi-drug resistance of paclitaxel and epothilone in cellular and animal models. Taccalonolides have captured numerous attention in the field of medicinal chemistry due to their variety of structures, unique mechanism of action, and low toxicity. This review focuses on the structural diversity, semi-synthesis, modification, and pharmacological activities of taccalonolides, providing bright thoughts for the discovery of microtubule-stabilizing drugs. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9407980/ /pubmed/36034793 http://dx.doi.org/10.3389/fphar.2022.968061 Text en Copyright © 2022 Li, Du, Gao, Xu, Zheng, Liu and Lei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Yan
Du, Yu-Feng
Gao, Feng
Xu, Jin-Bu
Zheng, Ling-Li
Liu, Gang
Lei, Yu
Taccalonolides: Structure, semi-synthesis, and biological activity
title Taccalonolides: Structure, semi-synthesis, and biological activity
title_full Taccalonolides: Structure, semi-synthesis, and biological activity
title_fullStr Taccalonolides: Structure, semi-synthesis, and biological activity
title_full_unstemmed Taccalonolides: Structure, semi-synthesis, and biological activity
title_short Taccalonolides: Structure, semi-synthesis, and biological activity
title_sort taccalonolides: structure, semi-synthesis, and biological activity
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407980/
https://www.ncbi.nlm.nih.gov/pubmed/36034793
http://dx.doi.org/10.3389/fphar.2022.968061
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