Indoloquinoline-Mediated Targeted Downregulation of KRAS through Selective Stabilization of the Mid-Promoter G-Quadruplex Structure

KRAS is a well-validated anti-cancer therapeutic target, whose transcriptional downregulation has been demonstrated to be lethal to tumor cells with aberrant KRAS signaling. G-quadruplexes (G4s) are non-canonical nucleic acid structures that mediate central dogmatic events, such as DNA repair, telom...

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Detalles Bibliográficos
Autores principales: Psaras, Alexandra Maria, Carty, Rhianna K., Miller, Jared T., Tumey, L. Nathan, Brooks, Tracy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408018/
https://www.ncbi.nlm.nih.gov/pubmed/36011352
http://dx.doi.org/10.3390/genes13081440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408018/
https://www.ncbi.nlm.nih.gov/pubmed/36011352
http://dx.doi.org/10.3390/genes13081440

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