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Changes in the Gut Microbiome and Pathologies in Pregnancy
Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregna...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408136/ https://www.ncbi.nlm.nih.gov/pubmed/36011603 http://dx.doi.org/10.3390/ijerph19169961 |
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author | Gorczyca, Kamila Obuchowska, Aleksandra Kimber-Trojnar, Żaneta Wierzchowska-Opoka, Magdalena Leszczyńska-Gorzelak, Bożena |
author_facet | Gorczyca, Kamila Obuchowska, Aleksandra Kimber-Trojnar, Żaneta Wierzchowska-Opoka, Magdalena Leszczyńska-Gorzelak, Bożena |
author_sort | Gorczyca, Kamila |
collection | PubMed |
description | Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora. |
format | Online Article Text |
id | pubmed-9408136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94081362022-08-26 Changes in the Gut Microbiome and Pathologies in Pregnancy Gorczyca, Kamila Obuchowska, Aleksandra Kimber-Trojnar, Żaneta Wierzchowska-Opoka, Magdalena Leszczyńska-Gorzelak, Bożena Int J Environ Res Public Health Review Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora. MDPI 2022-08-12 /pmc/articles/PMC9408136/ /pubmed/36011603 http://dx.doi.org/10.3390/ijerph19169961 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gorczyca, Kamila Obuchowska, Aleksandra Kimber-Trojnar, Żaneta Wierzchowska-Opoka, Magdalena Leszczyńska-Gorzelak, Bożena Changes in the Gut Microbiome and Pathologies in Pregnancy |
title | Changes in the Gut Microbiome and Pathologies in Pregnancy |
title_full | Changes in the Gut Microbiome and Pathologies in Pregnancy |
title_fullStr | Changes in the Gut Microbiome and Pathologies in Pregnancy |
title_full_unstemmed | Changes in the Gut Microbiome and Pathologies in Pregnancy |
title_short | Changes in the Gut Microbiome and Pathologies in Pregnancy |
title_sort | changes in the gut microbiome and pathologies in pregnancy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408136/ https://www.ncbi.nlm.nih.gov/pubmed/36011603 http://dx.doi.org/10.3390/ijerph19169961 |
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