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Changes in the Gut Microbiome and Pathologies in Pregnancy

Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregna...

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Autores principales: Gorczyca, Kamila, Obuchowska, Aleksandra, Kimber-Trojnar, Żaneta, Wierzchowska-Opoka, Magdalena, Leszczyńska-Gorzelak, Bożena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408136/
https://www.ncbi.nlm.nih.gov/pubmed/36011603
http://dx.doi.org/10.3390/ijerph19169961
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author Gorczyca, Kamila
Obuchowska, Aleksandra
Kimber-Trojnar, Żaneta
Wierzchowska-Opoka, Magdalena
Leszczyńska-Gorzelak, Bożena
author_facet Gorczyca, Kamila
Obuchowska, Aleksandra
Kimber-Trojnar, Żaneta
Wierzchowska-Opoka, Magdalena
Leszczyńska-Gorzelak, Bożena
author_sort Gorczyca, Kamila
collection PubMed
description Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora.
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spelling pubmed-94081362022-08-26 Changes in the Gut Microbiome and Pathologies in Pregnancy Gorczyca, Kamila Obuchowska, Aleksandra Kimber-Trojnar, Żaneta Wierzchowska-Opoka, Magdalena Leszczyńska-Gorzelak, Bożena Int J Environ Res Public Health Review Pregnancy is a special period in a woman’s life when her organism undergoes multiple physiological changes so that the fetus has optimal conditions for growth and development. These include modifications in the composition of the microbiome that occur between the first and third trimesters of pregnancy. There is an increase in Akkermansia, Bifidobacterium, and Firmicutes, which have been associated with an increase in the need for energy storage. The growth in Proteobacteria and Actinobacteria levels has a protective effect on both the mother and the fetus via proinflammatory mechanisms. The aim of the study is to review the research on the relationship between the mother’s intestinal microbiome and gestational pathologies. Changes in the maternal gut microbiome is probably one of the mechanisms that occurs in various pregnancy diseases such as preeclampsia, fetal growth restriction, gestational diabetes mellitus, excessive gestational weight gain, and premature birth. For this reason, it seems vital to pay attention to certain interventions that can benefit the affected patients both in the short term, by preventing complications during pregnancy, and in the long term, as one of the mechanisms occurring in various gestational diseases is dysbiosis of the maternal intestinal flora. MDPI 2022-08-12 /pmc/articles/PMC9408136/ /pubmed/36011603 http://dx.doi.org/10.3390/ijerph19169961 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gorczyca, Kamila
Obuchowska, Aleksandra
Kimber-Trojnar, Żaneta
Wierzchowska-Opoka, Magdalena
Leszczyńska-Gorzelak, Bożena
Changes in the Gut Microbiome and Pathologies in Pregnancy
title Changes in the Gut Microbiome and Pathologies in Pregnancy
title_full Changes in the Gut Microbiome and Pathologies in Pregnancy
title_fullStr Changes in the Gut Microbiome and Pathologies in Pregnancy
title_full_unstemmed Changes in the Gut Microbiome and Pathologies in Pregnancy
title_short Changes in the Gut Microbiome and Pathologies in Pregnancy
title_sort changes in the gut microbiome and pathologies in pregnancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408136/
https://www.ncbi.nlm.nih.gov/pubmed/36011603
http://dx.doi.org/10.3390/ijerph19169961
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