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Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR

In the present review, the main features involved in the susceptibility and progression of neurodegenerative disorders (NDDs) have been discussed, with the purpose of highlighting their potential application for promoting the management and treatment of patients with NDDs. In particular, the impact...

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Autores principales: Barati, Shila, Fabrizio, Carlo, Strafella, Claudia, Cascella, Raffaella, Caputo, Valerio, Megalizzi, Domenica, Peconi, Cristina, Mela, Julia, Colantoni, Luca, Caltagirone, Carlo, Termine, Andrea, Giardina, Emiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408177/
https://www.ncbi.nlm.nih.gov/pubmed/36011409
http://dx.doi.org/10.3390/genes13081498
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author Barati, Shila
Fabrizio, Carlo
Strafella, Claudia
Cascella, Raffaella
Caputo, Valerio
Megalizzi, Domenica
Peconi, Cristina
Mela, Julia
Colantoni, Luca
Caltagirone, Carlo
Termine, Andrea
Giardina, Emiliano
author_facet Barati, Shila
Fabrizio, Carlo
Strafella, Claudia
Cascella, Raffaella
Caputo, Valerio
Megalizzi, Domenica
Peconi, Cristina
Mela, Julia
Colantoni, Luca
Caltagirone, Carlo
Termine, Andrea
Giardina, Emiliano
author_sort Barati, Shila
collection PubMed
description In the present review, the main features involved in the susceptibility and progression of neurodegenerative disorders (NDDs) have been discussed, with the purpose of highlighting their potential application for promoting the management and treatment of patients with NDDs. In particular, the impact of genetic and epigenetic factors, nutrients, and lifestyle will be presented, with particular emphasis on Alzheimer’s disease (AD) and Parkinson’s disease (PD). Metabolism, dietary habits, physical exercise and microbiota are part of a complex network that is crucial for brain function and preservation. This complex equilibrium can be disrupted by genetic, epigenetic, and environmental factors causing perturbations in central nervous system homeostasis, contributing thereby to neuroinflammation and neurodegeneration. Diet and physical activity can directly act on epigenetic modifications, which, in turn, alter the expression of specific genes involved in NDDs onset and progression. On this subject, the introduction of nutrigenomics shed light on the main molecular players involved in the modulation of health and disease status. In particular, the review presents data concerning the impact of ADH1B, CYP1A2, and MTHFR on the susceptibility and progression of NDDs (especially AD and PD) and how they may be exploited for developing precision medicine strategies for the disease treatment and management.
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spelling pubmed-94081772022-08-26 Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR Barati, Shila Fabrizio, Carlo Strafella, Claudia Cascella, Raffaella Caputo, Valerio Megalizzi, Domenica Peconi, Cristina Mela, Julia Colantoni, Luca Caltagirone, Carlo Termine, Andrea Giardina, Emiliano Genes (Basel) Review In the present review, the main features involved in the susceptibility and progression of neurodegenerative disorders (NDDs) have been discussed, with the purpose of highlighting their potential application for promoting the management and treatment of patients with NDDs. In particular, the impact of genetic and epigenetic factors, nutrients, and lifestyle will be presented, with particular emphasis on Alzheimer’s disease (AD) and Parkinson’s disease (PD). Metabolism, dietary habits, physical exercise and microbiota are part of a complex network that is crucial for brain function and preservation. This complex equilibrium can be disrupted by genetic, epigenetic, and environmental factors causing perturbations in central nervous system homeostasis, contributing thereby to neuroinflammation and neurodegeneration. Diet and physical activity can directly act on epigenetic modifications, which, in turn, alter the expression of specific genes involved in NDDs onset and progression. On this subject, the introduction of nutrigenomics shed light on the main molecular players involved in the modulation of health and disease status. In particular, the review presents data concerning the impact of ADH1B, CYP1A2, and MTHFR on the susceptibility and progression of NDDs (especially AD and PD) and how they may be exploited for developing precision medicine strategies for the disease treatment and management. MDPI 2022-08-22 /pmc/articles/PMC9408177/ /pubmed/36011409 http://dx.doi.org/10.3390/genes13081498 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barati, Shila
Fabrizio, Carlo
Strafella, Claudia
Cascella, Raffaella
Caputo, Valerio
Megalizzi, Domenica
Peconi, Cristina
Mela, Julia
Colantoni, Luca
Caltagirone, Carlo
Termine, Andrea
Giardina, Emiliano
Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR
title Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR
title_full Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR
title_fullStr Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR
title_full_unstemmed Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR
title_short Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR
title_sort relationship between nutrition, lifestyle, and neurodegenerative disease: lessons from adh1b, cyp1a2 and mthfr
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408177/
https://www.ncbi.nlm.nih.gov/pubmed/36011409
http://dx.doi.org/10.3390/genes13081498
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