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Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis

Modic changes (MCs) are believed to be potential pain generators in the lumbar and cervical spine, but it is currently unclear if their presence affects postsurgical outcomes. We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (...

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Autores principales: Lambrechts, Mark J., Brush, Parker, Issa, Tariq Z., Toci, Gregory R., Heard, Jeremy C., Syal, Amit, Schilken, Meghan M., Canseco, Jose A., Kepler, Christopher K., Vaccaro, Alexander R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408205/
https://www.ncbi.nlm.nih.gov/pubmed/36011795
http://dx.doi.org/10.3390/ijerph191610158
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author Lambrechts, Mark J.
Brush, Parker
Issa, Tariq Z.
Toci, Gregory R.
Heard, Jeremy C.
Syal, Amit
Schilken, Meghan M.
Canseco, Jose A.
Kepler, Christopher K.
Vaccaro, Alexander R.
author_facet Lambrechts, Mark J.
Brush, Parker
Issa, Tariq Z.
Toci, Gregory R.
Heard, Jeremy C.
Syal, Amit
Schilken, Meghan M.
Canseco, Jose A.
Kepler, Christopher K.
Vaccaro, Alexander R.
author_sort Lambrechts, Mark J.
collection PubMed
description Modic changes (MCs) are believed to be potential pain generators in the lumbar and cervical spine, but it is currently unclear if their presence affects postsurgical outcomes. We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies evaluating cervical or lumbar spine postsurgical outcomes in patients with documented preoperative MCs were included. A total of 29 studies and 6013 patients with 2688 of those patients having preoperative MCs were included. Eight included studies evaluated cervical spine surgery, eleven evaluated lumbar discectomies, nine studied lumbar fusion surgery, and three assessed lumbar disc replacements. The presence of cervical MCs did not impact the clinical outcomes in the cervical spine procedures. Moreover, most studies found that MCs did not significantly impact the clinical outcomes following lumbar fusion, lumbar discectomy, or lumbar disc replacement. A meta-analysis of the relevant data found no significant association between MCs and VAS back pain or ODI following lumbar discectomy. Similarly, there was no association between MCs and JOA or neck pain following ACDF procedures. Patients with MC experienced statistically significant improvements following lumbar or cervical spine surgery. The postoperative improvements were similar to patients without MCs in the cervical and lumbar spine.
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spelling pubmed-94082052022-08-26 Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis Lambrechts, Mark J. Brush, Parker Issa, Tariq Z. Toci, Gregory R. Heard, Jeremy C. Syal, Amit Schilken, Meghan M. Canseco, Jose A. Kepler, Christopher K. Vaccaro, Alexander R. Int J Environ Res Public Health Review Modic changes (MCs) are believed to be potential pain generators in the lumbar and cervical spine, but it is currently unclear if their presence affects postsurgical outcomes. We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies evaluating cervical or lumbar spine postsurgical outcomes in patients with documented preoperative MCs were included. A total of 29 studies and 6013 patients with 2688 of those patients having preoperative MCs were included. Eight included studies evaluated cervical spine surgery, eleven evaluated lumbar discectomies, nine studied lumbar fusion surgery, and three assessed lumbar disc replacements. The presence of cervical MCs did not impact the clinical outcomes in the cervical spine procedures. Moreover, most studies found that MCs did not significantly impact the clinical outcomes following lumbar fusion, lumbar discectomy, or lumbar disc replacement. A meta-analysis of the relevant data found no significant association between MCs and VAS back pain or ODI following lumbar discectomy. Similarly, there was no association between MCs and JOA or neck pain following ACDF procedures. Patients with MC experienced statistically significant improvements following lumbar or cervical spine surgery. The postoperative improvements were similar to patients without MCs in the cervical and lumbar spine. MDPI 2022-08-16 /pmc/articles/PMC9408205/ /pubmed/36011795 http://dx.doi.org/10.3390/ijerph191610158 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lambrechts, Mark J.
Brush, Parker
Issa, Tariq Z.
Toci, Gregory R.
Heard, Jeremy C.
Syal, Amit
Schilken, Meghan M.
Canseco, Jose A.
Kepler, Christopher K.
Vaccaro, Alexander R.
Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis
title Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis
title_full Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis
title_fullStr Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis
title_full_unstemmed Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis
title_short Evaluating the Impact of Modic Changes on Operative Treatment in the Cervical and Lumbar Spine: A Systematic Review and Meta-Analysis
title_sort evaluating the impact of modic changes on operative treatment in the cervical and lumbar spine: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408205/
https://www.ncbi.nlm.nih.gov/pubmed/36011795
http://dx.doi.org/10.3390/ijerph191610158
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