Cargando…
Epigenetic Alterations in Sports-Related Injuries
It is a well-known fact that physical activity benefits people of all age groups. However, highly intensive training, maladaptation, improper equipment, and lack of sufficient rest lead to contusions and sports-related injuries. From the perspectives of sports professionals and those performing regu...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408207/ https://www.ncbi.nlm.nih.gov/pubmed/36011382 http://dx.doi.org/10.3390/genes13081471 |
_version_ | 1784774550807904256 |
---|---|
author | Tarnowski, Maciej Tomasiak, Patrycja Tkacz, Marta Zgutka, Katarzyna Piotrowska, Katarzyna |
author_facet | Tarnowski, Maciej Tomasiak, Patrycja Tkacz, Marta Zgutka, Katarzyna Piotrowska, Katarzyna |
author_sort | Tarnowski, Maciej |
collection | PubMed |
description | It is a well-known fact that physical activity benefits people of all age groups. However, highly intensive training, maladaptation, improper equipment, and lack of sufficient rest lead to contusions and sports-related injuries. From the perspectives of sports professionals and those performing regular–amateur sports activities, it is important to maintain proper levels of training, without encountering frequent injuries. The bodily responses to physical stress and intensive physical activity are detected on many levels. Epigenetic modifications, including DNA methylation, histone protein methylation, acetylation, and miRNA expression occur in response to environmental changes and play fundamental roles in the regulation of cellular activities. In the current review, we summarise the available knowledge on epigenetic alterations present in tissues and organs (e.g., muscles, the brain, tendons, and bones) as a consequence of sports-related injuries. Epigenetic mechanism observations have the potential to become useful tools in sports medicine, as predictors of approaching pathophysiological alterations and injury biomarkers that have already taken place. |
format | Online Article Text |
id | pubmed-9408207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94082072022-08-26 Epigenetic Alterations in Sports-Related Injuries Tarnowski, Maciej Tomasiak, Patrycja Tkacz, Marta Zgutka, Katarzyna Piotrowska, Katarzyna Genes (Basel) Review It is a well-known fact that physical activity benefits people of all age groups. However, highly intensive training, maladaptation, improper equipment, and lack of sufficient rest lead to contusions and sports-related injuries. From the perspectives of sports professionals and those performing regular–amateur sports activities, it is important to maintain proper levels of training, without encountering frequent injuries. The bodily responses to physical stress and intensive physical activity are detected on many levels. Epigenetic modifications, including DNA methylation, histone protein methylation, acetylation, and miRNA expression occur in response to environmental changes and play fundamental roles in the regulation of cellular activities. In the current review, we summarise the available knowledge on epigenetic alterations present in tissues and organs (e.g., muscles, the brain, tendons, and bones) as a consequence of sports-related injuries. Epigenetic mechanism observations have the potential to become useful tools in sports medicine, as predictors of approaching pathophysiological alterations and injury biomarkers that have already taken place. MDPI 2022-08-17 /pmc/articles/PMC9408207/ /pubmed/36011382 http://dx.doi.org/10.3390/genes13081471 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tarnowski, Maciej Tomasiak, Patrycja Tkacz, Marta Zgutka, Katarzyna Piotrowska, Katarzyna Epigenetic Alterations in Sports-Related Injuries |
title | Epigenetic Alterations in Sports-Related Injuries |
title_full | Epigenetic Alterations in Sports-Related Injuries |
title_fullStr | Epigenetic Alterations in Sports-Related Injuries |
title_full_unstemmed | Epigenetic Alterations in Sports-Related Injuries |
title_short | Epigenetic Alterations in Sports-Related Injuries |
title_sort | epigenetic alterations in sports-related injuries |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408207/ https://www.ncbi.nlm.nih.gov/pubmed/36011382 http://dx.doi.org/10.3390/genes13081471 |
work_keys_str_mv | AT tarnowskimaciej epigeneticalterationsinsportsrelatedinjuries AT tomasiakpatrycja epigeneticalterationsinsportsrelatedinjuries AT tkaczmarta epigeneticalterationsinsportsrelatedinjuries AT zgutkakatarzyna epigeneticalterationsinsportsrelatedinjuries AT piotrowskakatarzyna epigeneticalterationsinsportsrelatedinjuries |