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Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents
Atopic dermatitis (AD), chronic hand eczema (CHE), and urticaria are common inflammatory skin diseases among adolescents and associated with air quality. However, the synergistic effects of ambient air pollution and second-hand smoke (SHS) have been unclear. We conducted a cross-sectional study incl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408277/ https://www.ncbi.nlm.nih.gov/pubmed/36011645 http://dx.doi.org/10.3390/ijerph191610011 |
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author | Liao, Mengting Xiao, Yi Li, Shenxin Su, Juan Li, Ji Zou, Bin Chen, Xiang Shen, Minxue |
author_facet | Liao, Mengting Xiao, Yi Li, Shenxin Su, Juan Li, Ji Zou, Bin Chen, Xiang Shen, Minxue |
author_sort | Liao, Mengting |
collection | PubMed |
description | Atopic dermatitis (AD), chronic hand eczema (CHE), and urticaria are common inflammatory skin diseases among adolescents and associated with air quality. However, the synergistic effects of ambient air pollution and second-hand smoke (SHS) have been unclear. We conducted a cross-sectional study including 20,138 Chinese college students where dermatological examinations and a questionnaire survey were carried out. A generalized linear mixed model was applied for the association between individualized exposure of O(3), CO, NO(2), SO(2), PM(2.5), and PM(10) and the prevalence of inflammatory skin diseases. Interactions between air pollutants and SHS were analyzed. As a result, CO, NO(2), SO(2), PM(2.5), and PM(10) were positively correlated with the prevalence of AD, CHE, and urticaria. Higher frequency of SHS exposure contributed to increased probabilities of AD (p = 0.042), CHE (p < 0.001), and urticaria (p = 0.002). Of note, CO (OR: 2.57 (1.16–5.69) in third quartile) and NO(2) (OR: 2.38 (1.07–5.27) in third quartile) had positive interactions with SHS for AD, and PM(2.5) synergized with SHS for CHE (OR: 2.25 (1.22–4.15) for second quartile). Subgroup analyses agreed with the synergistic results. In conclusion, SHS and ambient air pollution are both associated with inflammatory skin diseases, and they have a synergistic effect on the prevalence of AD and CHE. |
format | Online Article Text |
id | pubmed-9408277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94082772022-08-26 Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents Liao, Mengting Xiao, Yi Li, Shenxin Su, Juan Li, Ji Zou, Bin Chen, Xiang Shen, Minxue Int J Environ Res Public Health Article Atopic dermatitis (AD), chronic hand eczema (CHE), and urticaria are common inflammatory skin diseases among adolescents and associated with air quality. However, the synergistic effects of ambient air pollution and second-hand smoke (SHS) have been unclear. We conducted a cross-sectional study including 20,138 Chinese college students where dermatological examinations and a questionnaire survey were carried out. A generalized linear mixed model was applied for the association between individualized exposure of O(3), CO, NO(2), SO(2), PM(2.5), and PM(10) and the prevalence of inflammatory skin diseases. Interactions between air pollutants and SHS were analyzed. As a result, CO, NO(2), SO(2), PM(2.5), and PM(10) were positively correlated with the prevalence of AD, CHE, and urticaria. Higher frequency of SHS exposure contributed to increased probabilities of AD (p = 0.042), CHE (p < 0.001), and urticaria (p = 0.002). Of note, CO (OR: 2.57 (1.16–5.69) in third quartile) and NO(2) (OR: 2.38 (1.07–5.27) in third quartile) had positive interactions with SHS for AD, and PM(2.5) synergized with SHS for CHE (OR: 2.25 (1.22–4.15) for second quartile). Subgroup analyses agreed with the synergistic results. In conclusion, SHS and ambient air pollution are both associated with inflammatory skin diseases, and they have a synergistic effect on the prevalence of AD and CHE. MDPI 2022-08-13 /pmc/articles/PMC9408277/ /pubmed/36011645 http://dx.doi.org/10.3390/ijerph191610011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liao, Mengting Xiao, Yi Li, Shenxin Su, Juan Li, Ji Zou, Bin Chen, Xiang Shen, Minxue Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents |
title | Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents |
title_full | Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents |
title_fullStr | Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents |
title_full_unstemmed | Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents |
title_short | Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents |
title_sort | synergistic effects between ambient air pollution and second-hand smoke on inflammatory skin diseases in chinese adolescents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408277/ https://www.ncbi.nlm.nih.gov/pubmed/36011645 http://dx.doi.org/10.3390/ijerph191610011 |
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