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Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme
The routine generation of enzymes with completely new active sites is a major unsolved problem in protein engineering. Advances in this field have thus far been modest, perhaps due, at least in part, to the widespread use of modern natural proteins as scaffolds for de novo engineering. Most modern p...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408544/ https://www.ncbi.nlm.nih.gov/pubmed/36012203 http://dx.doi.org/10.3390/ijms23168934 |