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Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder
The study aims at looking into associations between the polymorphism rs6276 that occurs in the putative miRNA target site in the 3′UTR region of the DRD2 gene in patients with substance use disorder (SUD) comorbid with a maniacal syndrome (SUD MANIA). In our study, we did not state any essential dif...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408599/ https://www.ncbi.nlm.nih.gov/pubmed/36011589 http://dx.doi.org/10.3390/ijerph19169955 |
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author | Boroń, Agnieszka Śmiarowska, Małgorzata Grzywacz, Anna Chmielowiec, Krzysztof Chmielowiec, Jolanta Masiak, Jolanta Pawłowski, Tomasz Larysz, Dariusz Ciechanowicz, Andrzej |
author_facet | Boroń, Agnieszka Śmiarowska, Małgorzata Grzywacz, Anna Chmielowiec, Krzysztof Chmielowiec, Jolanta Masiak, Jolanta Pawłowski, Tomasz Larysz, Dariusz Ciechanowicz, Andrzej |
author_sort | Boroń, Agnieszka |
collection | PubMed |
description | The study aims at looking into associations between the polymorphism rs6276 that occurs in the putative miRNA target site in the 3′UTR region of the DRD2 gene in patients with substance use disorder (SUD) comorbid with a maniacal syndrome (SUD MANIA). In our study, we did not state any essential difference in DRD2 rs6276 genotype frequencies in the studied samples of SUD MANIA, SUD, and control subjects. A significant result was found for the SUD MANIA group vs. SUD vs. controls on the Neuroticism Scale of NEO FFI test, and DRD2 rs6276 (p = 0.0320) accounted for 1.7% of the variance. The G/G homozygous variants were linked with lower results on the neuroticism scale in the SUD MANIA group because G/G alleles may serve a protective role in the expression of neuroticism in patients with SUD MANIA. So far, there have been no data in the literature on the relationship between the miRSNP rs6276 region in the DRD2 gene and neuroticism (personal traits) in patients with a diagnosis of substance use disorder comorbid with the affective, maniacal type disturbances related to SUD. This is the first report on this topic. |
format | Online Article Text |
id | pubmed-9408599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94085992022-08-26 Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder Boroń, Agnieszka Śmiarowska, Małgorzata Grzywacz, Anna Chmielowiec, Krzysztof Chmielowiec, Jolanta Masiak, Jolanta Pawłowski, Tomasz Larysz, Dariusz Ciechanowicz, Andrzej Int J Environ Res Public Health Article The study aims at looking into associations between the polymorphism rs6276 that occurs in the putative miRNA target site in the 3′UTR region of the DRD2 gene in patients with substance use disorder (SUD) comorbid with a maniacal syndrome (SUD MANIA). In our study, we did not state any essential difference in DRD2 rs6276 genotype frequencies in the studied samples of SUD MANIA, SUD, and control subjects. A significant result was found for the SUD MANIA group vs. SUD vs. controls on the Neuroticism Scale of NEO FFI test, and DRD2 rs6276 (p = 0.0320) accounted for 1.7% of the variance. The G/G homozygous variants were linked with lower results on the neuroticism scale in the SUD MANIA group because G/G alleles may serve a protective role in the expression of neuroticism in patients with SUD MANIA. So far, there have been no data in the literature on the relationship between the miRSNP rs6276 region in the DRD2 gene and neuroticism (personal traits) in patients with a diagnosis of substance use disorder comorbid with the affective, maniacal type disturbances related to SUD. This is the first report on this topic. MDPI 2022-08-12 /pmc/articles/PMC9408599/ /pubmed/36011589 http://dx.doi.org/10.3390/ijerph19169955 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boroń, Agnieszka Śmiarowska, Małgorzata Grzywacz, Anna Chmielowiec, Krzysztof Chmielowiec, Jolanta Masiak, Jolanta Pawłowski, Tomasz Larysz, Dariusz Ciechanowicz, Andrzej Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder |
title | Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder |
title_full | Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder |
title_fullStr | Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder |
title_full_unstemmed | Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder |
title_short | Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder |
title_sort | association of polymorphism within the putative mirna target site in the 3′utr region of the drd2 gene with neuroticism in patients with substance use disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408599/ https://www.ncbi.nlm.nih.gov/pubmed/36011589 http://dx.doi.org/10.3390/ijerph19169955 |
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