Cytokine Storm Signature in Patients with Moderate and Severe COVID-19

Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infec...

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Autores principales: Kalinina, Olga, Golovkin, Alexey, Zaikova, Ekaterina, Aquino, Arthur, Bezrukikh, Vadim, Melnik, Olesya, Vasilieva, Elena, Karonova, Tatiana, Kudryavtsev, Igor, Shlyakhto, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408700/
https://www.ncbi.nlm.nih.gov/pubmed/36012146
http://dx.doi.org/10.3390/ijms23168879
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author Kalinina, Olga
Golovkin, Alexey
Zaikova, Ekaterina
Aquino, Arthur
Bezrukikh, Vadim
Melnik, Olesya
Vasilieva, Elena
Karonova, Tatiana
Kudryavtsev, Igor
Shlyakhto, Evgeny
author_facet Kalinina, Olga
Golovkin, Alexey
Zaikova, Ekaterina
Aquino, Arthur
Bezrukikh, Vadim
Melnik, Olesya
Vasilieva, Elena
Karonova, Tatiana
Kudryavtsev, Igor
Shlyakhto, Evgeny
author_sort Kalinina, Olga
collection PubMed
description Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infection. Plasma levels of 47 cytokines were investigated in 73 patients with moderate and severe COVID-19 (41 and 32, respectively) and 11 healthy donors (HD). The most elevated levels comparing patients and the HD were observed for seven pro-inflammatory cytokines (IL-6, IL-8, IL-15, IL-18, IL-27, IFNγ, TNFα), three chemokines (GROα, IP-10, MIG), two anti-inflammatory cytokines (IL-1RA, IL-10), and two growth factors (G-CSF, M-CSF). The patients with severe disease had significantly higher levels of FGF-2/FGF-basic, IL-1β, and IL-7 compared to the HD. The two groups of patients differed from each other only based on the levels of EGF, eotaxin, and IL-12 p40. Pneumonia lung injury, characterized by computer tomography, positively correlated with levels of EGF, IP-10, MCP-3 levels and negatively with IL-12 p40. Pro-inflammatory factors including IL-6, TNFα, and IP-10 negatively correlated with the frequency of the circulating T-helper17-like cells (Th17-like) and follicular Th cells that are crucial to develop SARS-CoV-2-specific plasma cells and memory B cells. Obtained data on the cytokine levels illustrate their influence on progression and severity of COVID-19.
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spelling pubmed-94087002022-08-26 Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 Kalinina, Olga Golovkin, Alexey Zaikova, Ekaterina Aquino, Arthur Bezrukikh, Vadim Melnik, Olesya Vasilieva, Elena Karonova, Tatiana Kudryavtsev, Igor Shlyakhto, Evgeny Int J Mol Sci Article Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infection. Plasma levels of 47 cytokines were investigated in 73 patients with moderate and severe COVID-19 (41 and 32, respectively) and 11 healthy donors (HD). The most elevated levels comparing patients and the HD were observed for seven pro-inflammatory cytokines (IL-6, IL-8, IL-15, IL-18, IL-27, IFNγ, TNFα), three chemokines (GROα, IP-10, MIG), two anti-inflammatory cytokines (IL-1RA, IL-10), and two growth factors (G-CSF, M-CSF). The patients with severe disease had significantly higher levels of FGF-2/FGF-basic, IL-1β, and IL-7 compared to the HD. The two groups of patients differed from each other only based on the levels of EGF, eotaxin, and IL-12 p40. Pneumonia lung injury, characterized by computer tomography, positively correlated with levels of EGF, IP-10, MCP-3 levels and negatively with IL-12 p40. Pro-inflammatory factors including IL-6, TNFα, and IP-10 negatively correlated with the frequency of the circulating T-helper17-like cells (Th17-like) and follicular Th cells that are crucial to develop SARS-CoV-2-specific plasma cells and memory B cells. Obtained data on the cytokine levels illustrate their influence on progression and severity of COVID-19. MDPI 2022-08-10 /pmc/articles/PMC9408700/ /pubmed/36012146 http://dx.doi.org/10.3390/ijms23168879 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalinina, Olga
Golovkin, Alexey
Zaikova, Ekaterina
Aquino, Arthur
Bezrukikh, Vadim
Melnik, Olesya
Vasilieva, Elena
Karonova, Tatiana
Kudryavtsev, Igor
Shlyakhto, Evgeny
Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
title Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
title_full Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
title_fullStr Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
title_full_unstemmed Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
title_short Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
title_sort cytokine storm signature in patients with moderate and severe covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408700/
https://www.ncbi.nlm.nih.gov/pubmed/36012146
http://dx.doi.org/10.3390/ijms23168879
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