Cytokine Storm Signature in Patients with Moderate and Severe COVID-19
Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infec...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408700/ https://www.ncbi.nlm.nih.gov/pubmed/36012146 http://dx.doi.org/10.3390/ijms23168879 |
_version_ | 1784774666437525504 |
---|---|
author | Kalinina, Olga Golovkin, Alexey Zaikova, Ekaterina Aquino, Arthur Bezrukikh, Vadim Melnik, Olesya Vasilieva, Elena Karonova, Tatiana Kudryavtsev, Igor Shlyakhto, Evgeny |
author_facet | Kalinina, Olga Golovkin, Alexey Zaikova, Ekaterina Aquino, Arthur Bezrukikh, Vadim Melnik, Olesya Vasilieva, Elena Karonova, Tatiana Kudryavtsev, Igor Shlyakhto, Evgeny |
author_sort | Kalinina, Olga |
collection | PubMed |
description | Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infection. Plasma levels of 47 cytokines were investigated in 73 patients with moderate and severe COVID-19 (41 and 32, respectively) and 11 healthy donors (HD). The most elevated levels comparing patients and the HD were observed for seven pro-inflammatory cytokines (IL-6, IL-8, IL-15, IL-18, IL-27, IFNγ, TNFα), three chemokines (GROα, IP-10, MIG), two anti-inflammatory cytokines (IL-1RA, IL-10), and two growth factors (G-CSF, M-CSF). The patients with severe disease had significantly higher levels of FGF-2/FGF-basic, IL-1β, and IL-7 compared to the HD. The two groups of patients differed from each other only based on the levels of EGF, eotaxin, and IL-12 p40. Pneumonia lung injury, characterized by computer tomography, positively correlated with levels of EGF, IP-10, MCP-3 levels and negatively with IL-12 p40. Pro-inflammatory factors including IL-6, TNFα, and IP-10 negatively correlated with the frequency of the circulating T-helper17-like cells (Th17-like) and follicular Th cells that are crucial to develop SARS-CoV-2-specific plasma cells and memory B cells. Obtained data on the cytokine levels illustrate their influence on progression and severity of COVID-19. |
format | Online Article Text |
id | pubmed-9408700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94087002022-08-26 Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 Kalinina, Olga Golovkin, Alexey Zaikova, Ekaterina Aquino, Arthur Bezrukikh, Vadim Melnik, Olesya Vasilieva, Elena Karonova, Tatiana Kudryavtsev, Igor Shlyakhto, Evgeny Int J Mol Sci Article Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was to describe cytokine storm signatures in patients with acute COVID-19 and to investigate their influence on severity of the infection. Plasma levels of 47 cytokines were investigated in 73 patients with moderate and severe COVID-19 (41 and 32, respectively) and 11 healthy donors (HD). The most elevated levels comparing patients and the HD were observed for seven pro-inflammatory cytokines (IL-6, IL-8, IL-15, IL-18, IL-27, IFNγ, TNFα), three chemokines (GROα, IP-10, MIG), two anti-inflammatory cytokines (IL-1RA, IL-10), and two growth factors (G-CSF, M-CSF). The patients with severe disease had significantly higher levels of FGF-2/FGF-basic, IL-1β, and IL-7 compared to the HD. The two groups of patients differed from each other only based on the levels of EGF, eotaxin, and IL-12 p40. Pneumonia lung injury, characterized by computer tomography, positively correlated with levels of EGF, IP-10, MCP-3 levels and negatively with IL-12 p40. Pro-inflammatory factors including IL-6, TNFα, and IP-10 negatively correlated with the frequency of the circulating T-helper17-like cells (Th17-like) and follicular Th cells that are crucial to develop SARS-CoV-2-specific plasma cells and memory B cells. Obtained data on the cytokine levels illustrate their influence on progression and severity of COVID-19. MDPI 2022-08-10 /pmc/articles/PMC9408700/ /pubmed/36012146 http://dx.doi.org/10.3390/ijms23168879 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kalinina, Olga Golovkin, Alexey Zaikova, Ekaterina Aquino, Arthur Bezrukikh, Vadim Melnik, Olesya Vasilieva, Elena Karonova, Tatiana Kudryavtsev, Igor Shlyakhto, Evgeny Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 |
title | Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 |
title_full | Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 |
title_fullStr | Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 |
title_full_unstemmed | Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 |
title_short | Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 |
title_sort | cytokine storm signature in patients with moderate and severe covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408700/ https://www.ncbi.nlm.nih.gov/pubmed/36012146 http://dx.doi.org/10.3390/ijms23168879 |
work_keys_str_mv | AT kalininaolga cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT golovkinalexey cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT zaikovaekaterina cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT aquinoarthur cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT bezrukikhvadim cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT melnikolesya cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT vasilievaelena cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT karonovatatiana cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT kudryavtsevigor cytokinestormsignatureinpatientswithmoderateandseverecovid19 AT shlyakhtoevgeny cytokinestormsignatureinpatientswithmoderateandseverecovid19 |