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Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy

In women, breast cancer (BC) is the most commonly diagnosed cancer (24.5%) and the leading cause of cancer death (15.5%). Understanding how this heterogeneous disease develops and the confirm mechanisms behind tumor progression is of utmost importance. Exosomes are long-range message vesicles that m...

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Detalles Bibliográficos
Autores principales: Shefer, Aleksei, Yalovaya, Alena, Tamkovich, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408748/
https://www.ncbi.nlm.nih.gov/pubmed/36012109
http://dx.doi.org/10.3390/ijms23168845
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author Shefer, Aleksei
Yalovaya, Alena
Tamkovich, Svetlana
author_facet Shefer, Aleksei
Yalovaya, Alena
Tamkovich, Svetlana
author_sort Shefer, Aleksei
collection PubMed
description In women, breast cancer (BC) is the most commonly diagnosed cancer (24.5%) and the leading cause of cancer death (15.5%). Understanding how this heterogeneous disease develops and the confirm mechanisms behind tumor progression is of utmost importance. Exosomes are long-range message vesicles that mediate communication between cells in physiological conditions but also in pathology, such as breast cancer. In recent years, there has been an exponential rise in the scientific studies reporting the change in morphology and cargo of tumor-derived exosomes. Due to the transfer of biologically active molecules, such as RNA (microRNA, long non-coding RNA, mRNA, etc.) and proteins (transcription factors, enzymes, etc.) into recipient cells, these lipid bilayer 30–150 nm vesicles activate numerous signaling pathways that promote tumor development. In this review, we attempt to shed light on exosomes’ involvement in breast cancer pathogenesis (including epithelial-to-mesenchymal transition (EMT), tumor cell proliferation and motility, metastatic processes, angiogenesis stimulation, and immune system repression). Moreover, the potential use of exosomes as promising diagnostic biomarkers for liquid biopsy of breast cancer is also discussed.
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spelling pubmed-94087482022-08-26 Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy Shefer, Aleksei Yalovaya, Alena Tamkovich, Svetlana Int J Mol Sci Review In women, breast cancer (BC) is the most commonly diagnosed cancer (24.5%) and the leading cause of cancer death (15.5%). Understanding how this heterogeneous disease develops and the confirm mechanisms behind tumor progression is of utmost importance. Exosomes are long-range message vesicles that mediate communication between cells in physiological conditions but also in pathology, such as breast cancer. In recent years, there has been an exponential rise in the scientific studies reporting the change in morphology and cargo of tumor-derived exosomes. Due to the transfer of biologically active molecules, such as RNA (microRNA, long non-coding RNA, mRNA, etc.) and proteins (transcription factors, enzymes, etc.) into recipient cells, these lipid bilayer 30–150 nm vesicles activate numerous signaling pathways that promote tumor development. In this review, we attempt to shed light on exosomes’ involvement in breast cancer pathogenesis (including epithelial-to-mesenchymal transition (EMT), tumor cell proliferation and motility, metastatic processes, angiogenesis stimulation, and immune system repression). Moreover, the potential use of exosomes as promising diagnostic biomarkers for liquid biopsy of breast cancer is also discussed. MDPI 2022-08-09 /pmc/articles/PMC9408748/ /pubmed/36012109 http://dx.doi.org/10.3390/ijms23168845 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shefer, Aleksei
Yalovaya, Alena
Tamkovich, Svetlana
Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy
title Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy
title_full Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy
title_fullStr Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy
title_full_unstemmed Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy
title_short Exosomes in Breast Cancer: Involvement in Tumor Dissemination and Prospects for Liquid Biopsy
title_sort exosomes in breast cancer: involvement in tumor dissemination and prospects for liquid biopsy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408748/
https://www.ncbi.nlm.nih.gov/pubmed/36012109
http://dx.doi.org/10.3390/ijms23168845
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