Uromodulin Regulates Murine Aquaporin−2 Activity via Thick Ascending Limb–Collecting Duct Cross−Talk during Water Deprivation

Uromodulin, a urinary protein synthesized and secreted from the thick ascending limb (TAL) of the loop of Henle, is associated with hypertension through the activation of sodium reabsorption in the TAL. Uromodulin is a potential target for hypertension treatment via natriuresis. However, its biologi...

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Detalles Bibliográficos
Autores principales: Takata, Tomoaki, Hamada, Shintaro, Mae, Yukari, Iyama, Takuji, Ogihara, Ryohei, Seno, Misako, Nakamura, Kazuomi, Takata, Miki, Sugihara, Takaaki, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408883/
https://www.ncbi.nlm.nih.gov/pubmed/36012675
http://dx.doi.org/10.3390/ijms23169410

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