Cargando…

TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis

The transmembrane protein 106B (TMEM106B) gene is a susceptibility factor and disease modifier of frontotemporal dementia, but few studies have investigated its role in amyotrophic lateral sclerosis. The aim of this work was to assess the impact of the TMEM106B rs1990622 (A–major risk allele; G–mino...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manini, Arianna, Ratti, Antonia, Brusati, Alberto, Maranzano, Alessio, Fogh, Isabella, Peverelli, Silvia, Messina, Stefano, Gentilini, Davide, Verde, Federico, Poletti, Barbara, Morelli, Claudia, Silani, Vincenzo, Ticozzi, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408885/ https://www.ncbi.nlm.nih.gov/pubmed/36012536 http://dx.doi.org/10.3390/ijms23169276

Ejemplares similares

Association of the risk factor UNC13A with survival and upper motor neuron involvement in amyotrophic lateral sclerosis
por: Manini, Arianna, et al.
Publicado: (2023)

Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis
por: Verde, Federico, et al.
Publicado: (2023)

Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis
por: Verde, Federico, et al.
Publicado: (2022)

Motor, cognitive and behavioural profiles of C9orf72 expansion-related amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2022)

Correction to: Motor, cognitive and behavioural profiles of C9orf72 expansion-related amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2023)

Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis
por: Maranzano, Alessio, et al.
Publicado: (2023)

Parkinsonian Syndromes in Motor Neuron Disease: A Clinical Study
por: Pasquini, Jacopo, et al.
Publicado: (2022)

Analysis of miRNA rare variants in amyotrophic lateral sclerosis and in silico prediction of their biological effects
por: Brusati, Alberto, et al.
Publicado: (2022)

Correlation between clinical phenotype and electromyographic parameters in amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2022)

Correction to: Correlation between clinical phenotype and electromyographic parameters in amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2023)

Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2023)

The impact of upper motor neuron involvement on clinical features, disease progression and prognosis in amyotrophic lateral sclerosis
por: Colombo, Eleonora, et al.
Publicado: (2023)

Serum neurofilament light chain levels in Covid-19 patients without major neurological manifestations
por: Verde, Federico, et al.
Publicado: (2022)

Feasibility and diagnostics of the Frontal Assessment Battery (FAB) in amyotrophic lateral sclerosis
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Prevalence and determinants of language impairment in non‐demented amyotrophic lateral sclerosis patients
por: Solca, Federica, et al.
Publicado: (2022)

Diagnostics and clinical usability of the Montreal Cognitive Assessment (MoCA) in amyotrophic lateral sclerosis
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Emotional Processing and Experience in Amyotrophic Lateral Sclerosis: A Systematic and Critical Review
por: Carelli, Laura, et al.
Publicado: (2021)

Epileptic Capgras-Like Delusions in a Patient with Right Frontal Meningioma: Case Report
por: Colombo, Eleonora, et al.
Publicado: (2021)

Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease
por: Perneel, Jolien, et al.
Publicado: (2022)

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes
por: T. Vicente, Cristina, et al.
Publicado: (2023)

TARDBP mutations in a cohort of Italian patients with Parkinson’s disease and atypical parkinsonisms
por: Tiloca, Cinzia, et al.
Publicado: (2022)

Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders
por: Poletti, Barbara, et al.
Publicado: (2021)

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment
por: Ishikawa, Ruoyi, et al.
Publicado: (2023)

Variation in TMEM106B in chronic traumatic encephalopathy
por: Cherry, Jonathan D., et al.
Publicado: (2018)

Lysosomal dysfunction in TMEM106B hypomyelinating leukodystrophy
por: Ito, Yoko, et al.
Publicado: (2018)

TMEM106A transcriptionally regulated by promoter methylation is involved in invasion and metastasis of hepatocellular carcinoma: TMEM106A is involved in invasion and metastasis of HCC
por: Shi, Shiming, et al.
Publicado: (2022)

The major TMEM106B dementia risk allele affects TMEM106B protein levels and myelin lipid homeostasis in the ageing human hippocampus
por: Lee, Jun Yup, et al.
Publicado: (2023)

TMEM106B expression is reduced in Alzheimer’s disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2014)

Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis
por: Carlomagno, C., et al.
Publicado: (2020)

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
por: Lee, Jun Yup, et al.
Publicado: (2023)

Clinical and molecular features of patients with amyotrophic lateral sclerosis and SOD1 mutations: a monocentric study
por: Gagliardi, Delia, et al.
Publicado: (2023)

Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Verde, Federico, et al.
Publicado: (2021)

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
por: Jiao, Hai-Shan, et al.
Publicado: (2023)

TMEM106B regulates microglial proliferation and survival in response to demyelination
por: Zhang, Tingting, et al.
Publicado: (2023)

The Frontal Assessment Battery (FAB) effectively discriminates between MCI and dementia within the clinical spectrum of neurochemically confirmed Alzheimer’s disease
por: Aiello, Edoardo Nicolò, et al.
Publicado: (2022)

Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease
por: Poletti, Barbara, et al.
Publicado: (2022)

TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
por: van der Zee, Julie, et al.
Publicado: (2011)

TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma
por: Duan, Jicheng, et al.
Publicado: (2021)

TMEM106A inhibits enveloped virus release from cell surface
por: Mao, Dexin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lpeecn5tbiu5nvlpas3mbbej54