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DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These interactions are highly regulated, and dysregulation c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408909/ https://www.ncbi.nlm.nih.gov/pubmed/36012592 http://dx.doi.org/10.3390/ijms23169329 |
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author | Bonczek, Ondrej Wang, Lixiao Gnanasundram, Sivakumar Vadivel Chen, Sa Haronikova, Lucia Zavadil-Kokas, Filip Vojtesek, Borivoj |
author_facet | Bonczek, Ondrej Wang, Lixiao Gnanasundram, Sivakumar Vadivel Chen, Sa Haronikova, Lucia Zavadil-Kokas, Filip Vojtesek, Borivoj |
author_sort | Bonczek, Ondrej |
collection | PubMed |
description | DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These interactions are highly regulated, and dysregulation contributes to the development of a variety of diseases, including cancer. An increasing number of proteins with DNA and/or RNA binding activities have been identified in recent years, and it is important to understand how their activities are related to the molecular mechanisms of cancer. In addition, many of these proteins have overlapping functions, and it is therefore essential to analyze not only the loss of function of individual factors, but also to group abnormalities into specific types of activities in regard to particular cancer types. In this review, we summarize the classes of DNA-binding, RNA-binding, and DRBPs, drawing particular attention to the similarities and differences between these protein classes. We also perform a cross-search analysis of relevant protein databases, together with our own pipeline, to identify DRBPs involved in cancer. We discuss the most common DRBPs and how they are related to specific cancers, reviewing their biochemical, molecular biological, and cellular properties to highlight their functions and potential as targets for treatment. |
format | Online Article Text |
id | pubmed-9408909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94089092022-08-26 DNA and RNA Binding Proteins: From Motifs to Roles in Cancer Bonczek, Ondrej Wang, Lixiao Gnanasundram, Sivakumar Vadivel Chen, Sa Haronikova, Lucia Zavadil-Kokas, Filip Vojtesek, Borivoj Int J Mol Sci Review DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These interactions are highly regulated, and dysregulation contributes to the development of a variety of diseases, including cancer. An increasing number of proteins with DNA and/or RNA binding activities have been identified in recent years, and it is important to understand how their activities are related to the molecular mechanisms of cancer. In addition, many of these proteins have overlapping functions, and it is therefore essential to analyze not only the loss of function of individual factors, but also to group abnormalities into specific types of activities in regard to particular cancer types. In this review, we summarize the classes of DNA-binding, RNA-binding, and DRBPs, drawing particular attention to the similarities and differences between these protein classes. We also perform a cross-search analysis of relevant protein databases, together with our own pipeline, to identify DRBPs involved in cancer. We discuss the most common DRBPs and how they are related to specific cancers, reviewing their biochemical, molecular biological, and cellular properties to highlight their functions and potential as targets for treatment. MDPI 2022-08-18 /pmc/articles/PMC9408909/ /pubmed/36012592 http://dx.doi.org/10.3390/ijms23169329 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bonczek, Ondrej Wang, Lixiao Gnanasundram, Sivakumar Vadivel Chen, Sa Haronikova, Lucia Zavadil-Kokas, Filip Vojtesek, Borivoj DNA and RNA Binding Proteins: From Motifs to Roles in Cancer |
title | DNA and RNA Binding Proteins: From Motifs to Roles in Cancer |
title_full | DNA and RNA Binding Proteins: From Motifs to Roles in Cancer |
title_fullStr | DNA and RNA Binding Proteins: From Motifs to Roles in Cancer |
title_full_unstemmed | DNA and RNA Binding Proteins: From Motifs to Roles in Cancer |
title_short | DNA and RNA Binding Proteins: From Motifs to Roles in Cancer |
title_sort | dna and rna binding proteins: from motifs to roles in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408909/ https://www.ncbi.nlm.nih.gov/pubmed/36012592 http://dx.doi.org/10.3390/ijms23169329 |
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