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DNA and RNA Binding Proteins: From Motifs to Roles in Cancer

DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These interactions are highly regulated, and dysregulation c...

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Autores principales: Bonczek, Ondrej, Wang, Lixiao, Gnanasundram, Sivakumar Vadivel, Chen, Sa, Haronikova, Lucia, Zavadil-Kokas, Filip, Vojtesek, Borivoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408909/
https://www.ncbi.nlm.nih.gov/pubmed/36012592
http://dx.doi.org/10.3390/ijms23169329
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author Bonczek, Ondrej
Wang, Lixiao
Gnanasundram, Sivakumar Vadivel
Chen, Sa
Haronikova, Lucia
Zavadil-Kokas, Filip
Vojtesek, Borivoj
author_facet Bonczek, Ondrej
Wang, Lixiao
Gnanasundram, Sivakumar Vadivel
Chen, Sa
Haronikova, Lucia
Zavadil-Kokas, Filip
Vojtesek, Borivoj
author_sort Bonczek, Ondrej
collection PubMed
description DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These interactions are highly regulated, and dysregulation contributes to the development of a variety of diseases, including cancer. An increasing number of proteins with DNA and/or RNA binding activities have been identified in recent years, and it is important to understand how their activities are related to the molecular mechanisms of cancer. In addition, many of these proteins have overlapping functions, and it is therefore essential to analyze not only the loss of function of individual factors, but also to group abnormalities into specific types of activities in regard to particular cancer types. In this review, we summarize the classes of DNA-binding, RNA-binding, and DRBPs, drawing particular attention to the similarities and differences between these protein classes. We also perform a cross-search analysis of relevant protein databases, together with our own pipeline, to identify DRBPs involved in cancer. We discuss the most common DRBPs and how they are related to specific cancers, reviewing their biochemical, molecular biological, and cellular properties to highlight their functions and potential as targets for treatment.
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spelling pubmed-94089092022-08-26 DNA and RNA Binding Proteins: From Motifs to Roles in Cancer Bonczek, Ondrej Wang, Lixiao Gnanasundram, Sivakumar Vadivel Chen, Sa Haronikova, Lucia Zavadil-Kokas, Filip Vojtesek, Borivoj Int J Mol Sci Review DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These interactions are highly regulated, and dysregulation contributes to the development of a variety of diseases, including cancer. An increasing number of proteins with DNA and/or RNA binding activities have been identified in recent years, and it is important to understand how their activities are related to the molecular mechanisms of cancer. In addition, many of these proteins have overlapping functions, and it is therefore essential to analyze not only the loss of function of individual factors, but also to group abnormalities into specific types of activities in regard to particular cancer types. In this review, we summarize the classes of DNA-binding, RNA-binding, and DRBPs, drawing particular attention to the similarities and differences between these protein classes. We also perform a cross-search analysis of relevant protein databases, together with our own pipeline, to identify DRBPs involved in cancer. We discuss the most common DRBPs and how they are related to specific cancers, reviewing their biochemical, molecular biological, and cellular properties to highlight their functions and potential as targets for treatment. MDPI 2022-08-18 /pmc/articles/PMC9408909/ /pubmed/36012592 http://dx.doi.org/10.3390/ijms23169329 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bonczek, Ondrej
Wang, Lixiao
Gnanasundram, Sivakumar Vadivel
Chen, Sa
Haronikova, Lucia
Zavadil-Kokas, Filip
Vojtesek, Borivoj
DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
title DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
title_full DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
title_fullStr DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
title_full_unstemmed DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
title_short DNA and RNA Binding Proteins: From Motifs to Roles in Cancer
title_sort dna and rna binding proteins: from motifs to roles in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408909/
https://www.ncbi.nlm.nih.gov/pubmed/36012592
http://dx.doi.org/10.3390/ijms23169329
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