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Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology

miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′ UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied....

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Detalles Bibliográficos
Autores principales: Morales-Martínez, Mario, Vega, Mario I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408913/
https://www.ncbi.nlm.nih.gov/pubmed/36012357
http://dx.doi.org/10.3390/ijms23169091
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author Morales-Martínez, Mario
Vega, Mario I.
author_facet Morales-Martínez, Mario
Vega, Mario I.
author_sort Morales-Martínez, Mario
collection PubMed
description miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′ UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied. In this context, miR-7 is described as an important factor in the development of cancer because of its role as a tumor suppressor, regulating a large number of genes involved in the development and progression of cancer. Recent data support the function of miR-7 as a prognostic biomarker in cancer, and miR-7 has been proposed as a strategy in cancer therapy. In this work, the role of miR-7 in various types of cancer is reviewed, illustrating its regulation, direct targets, and effects, as well as its possible relationship to the clinical outcome of cancer patients.
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spelling pubmed-94089132022-08-26 Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology Morales-Martínez, Mario Vega, Mario I. Int J Mol Sci Review miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′ UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied. In this context, miR-7 is described as an important factor in the development of cancer because of its role as a tumor suppressor, regulating a large number of genes involved in the development and progression of cancer. Recent data support the function of miR-7 as a prognostic biomarker in cancer, and miR-7 has been proposed as a strategy in cancer therapy. In this work, the role of miR-7 in various types of cancer is reviewed, illustrating its regulation, direct targets, and effects, as well as its possible relationship to the clinical outcome of cancer patients. MDPI 2022-08-13 /pmc/articles/PMC9408913/ /pubmed/36012357 http://dx.doi.org/10.3390/ijms23169091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Morales-Martínez, Mario
Vega, Mario I.
Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
title Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
title_full Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
title_fullStr Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
title_full_unstemmed Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
title_short Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
title_sort role of microrna-7 (mir-7) in cancer physiopathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408913/
https://www.ncbi.nlm.nih.gov/pubmed/36012357
http://dx.doi.org/10.3390/ijms23169091
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