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Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology
miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′ UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408913/ https://www.ncbi.nlm.nih.gov/pubmed/36012357 http://dx.doi.org/10.3390/ijms23169091 |
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author | Morales-Martínez, Mario Vega, Mario I. |
author_facet | Morales-Martínez, Mario Vega, Mario I. |
author_sort | Morales-Martínez, Mario |
collection | PubMed |
description | miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′ UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied. In this context, miR-7 is described as an important factor in the development of cancer because of its role as a tumor suppressor, regulating a large number of genes involved in the development and progression of cancer. Recent data support the function of miR-7 as a prognostic biomarker in cancer, and miR-7 has been proposed as a strategy in cancer therapy. In this work, the role of miR-7 in various types of cancer is reviewed, illustrating its regulation, direct targets, and effects, as well as its possible relationship to the clinical outcome of cancer patients. |
format | Online Article Text |
id | pubmed-9408913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94089132022-08-26 Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology Morales-Martínez, Mario Vega, Mario I. Int J Mol Sci Review miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′ UTR regions. Following their discovery, the role they play in the development of various pathologies, particularly cancer, has been studied. In this context, miR-7 is described as an important factor in the development of cancer because of its role as a tumor suppressor, regulating a large number of genes involved in the development and progression of cancer. Recent data support the function of miR-7 as a prognostic biomarker in cancer, and miR-7 has been proposed as a strategy in cancer therapy. In this work, the role of miR-7 in various types of cancer is reviewed, illustrating its regulation, direct targets, and effects, as well as its possible relationship to the clinical outcome of cancer patients. MDPI 2022-08-13 /pmc/articles/PMC9408913/ /pubmed/36012357 http://dx.doi.org/10.3390/ijms23169091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Morales-Martínez, Mario Vega, Mario I. Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology |
title | Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology |
title_full | Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology |
title_fullStr | Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology |
title_full_unstemmed | Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology |
title_short | Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology |
title_sort | role of microrna-7 (mir-7) in cancer physiopathology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408913/ https://www.ncbi.nlm.nih.gov/pubmed/36012357 http://dx.doi.org/10.3390/ijms23169091 |
work_keys_str_mv | AT moralesmartinezmario roleofmicrorna7mir7incancerphysiopathology AT vegamarioi roleofmicrorna7mir7incancerphysiopathology |