The Omnipresence of DYRK1A in Human Diseases

The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug c...

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Detalles Bibliográficos
Autores principales: Deboever, Estelle, Fistrovich, Alessandra, Hulme, Christopher, Dunckley, Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408930/
https://www.ncbi.nlm.nih.gov/pubmed/36012629
http://dx.doi.org/10.3390/ijms23169355
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author Deboever, Estelle
Fistrovich, Alessandra
Hulme, Christopher
Dunckley, Travis
author_facet Deboever, Estelle
Fistrovich, Alessandra
Hulme, Christopher
Dunckley, Travis
author_sort Deboever, Estelle
collection PubMed
description The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.
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spelling pubmed-94089302022-08-26 The Omnipresence of DYRK1A in Human Diseases Deboever, Estelle Fistrovich, Alessandra Hulme, Christopher Dunckley, Travis Int J Mol Sci Review The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential. MDPI 2022-08-19 /pmc/articles/PMC9408930/ /pubmed/36012629 http://dx.doi.org/10.3390/ijms23169355 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Deboever, Estelle
Fistrovich, Alessandra
Hulme, Christopher
Dunckley, Travis
The Omnipresence of DYRK1A in Human Diseases
title The Omnipresence of DYRK1A in Human Diseases
title_full The Omnipresence of DYRK1A in Human Diseases
title_fullStr The Omnipresence of DYRK1A in Human Diseases
title_full_unstemmed The Omnipresence of DYRK1A in Human Diseases
title_short The Omnipresence of DYRK1A in Human Diseases
title_sort omnipresence of dyrk1a in human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408930/
https://www.ncbi.nlm.nih.gov/pubmed/36012629
http://dx.doi.org/10.3390/ijms23169355
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