Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist

We report the design, synthesis, and validation of the novel compound photocaged N(6)-cyclopentyladenosine (cCPA) to achieve precisely localized and timed release of the parent adenosine A1 receptor agonist CPA using 405 nm light. G(i) protein-coupled A(1) receptors (A(1)Rs) modulate neurotransmissi...

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Detalles Bibliográficos
Autores principales: Craey, Erine, Hulpia, Fabian, Spanoghe, Jeroen, Manzella, Simona, Larsen, Lars E., Sprengers, Mathieu, De Bundel, Dimitri, Smolders, Ilse, Carrette, Evelien, Delbeke, Jean, Vonck, Kristl, Boon, Paul, Van Calenbergh, Serge, Wadman, Wytse J., Raedt, Robrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408941/
https://www.ncbi.nlm.nih.gov/pubmed/36012151
http://dx.doi.org/10.3390/ijms23168887

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